Composite Bone Grafts Using Polymeric Binders
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Solution Overview
Problem
Conventional bone graft technologies do not effectively utilize bone particles or dust generated during processing, leading to waste and limiting the benefits of donor gifts, and often result in grafts with inconsistent mechanical properties and poor integration with natural bone.
Innovation Solution
A bone graft composition using human cadaveric bone material immobilized in a polymeric binder, such as polylactic acid or cyanoacrylate, which promotes cohesion and can be machined into desired shapes, with adjustable properties to match natural bone, and a method involving centrifugation or isostatic pressure to create a strong, flexible composite.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Loss of substance
If bone particles are used as waste material without processing, then material utilization is poor, but creating structured grafts requires additional processing steps
Solution Approach 1:
The invention recovers bone particles that would normally be discarded as waste during bone processing. These particles are collected and reprocessed into structured grafts, thereby reducing material loss and maximizing the utilization of donor bone tissue.
Solution Approach 2:
The bone processing is segmented into distinct stages: initial bone preparation, particle collection, particle processing (demineralization, sizing), binder application, and final graft formation. This segmentation allows each step to be optimized independently while maintaining overall efficiency.
2Ease of manufacture
If bone particles are simply aggregated without binding, then manufacturing is simple, but mechanical strength and structural integrity are insufficient
Solution Approach 1:
The invention creates a composite material system combining bone particles with polymeric binders. The bone particles provide the structural framework and biological functionality, while the polymeric binder (such as polylactic acid or cyanoacrylate) provides mechanical strength and cohesion, resulting in a composite graft with both ease of manufacture and sufficient strength.
3Loss of substance
If graft size is increased to maximize donor material utility, then material utilization improves, but implantation difficulty and integration challenges increase
Solution Approach 1:
The final graft is segmented into smaller, manageable particles that can be easily implanted. These particles are then bound together in situ or pre-assembled into configurable structures, allowing maximum utilization of donor material while maintaining ease of implantation and integration with the patient's anatomy.
4Reliability
If consistent mechanical properties are achieved through processing, then graft reliability improves, but processing complexity increases
Solution Approach 1:
The invention controls key processing parameters such as particle size distribution, demineralization extent, binder concentration, and curing conditions to achieve consistent mechanical properties. By standardizing these parameters across processing batches, reliable and predictable graft performance is achieved while maintaining a manageable processing procedure.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution enables the creation of bone grafts with consistent mechanical properties similar to natural bone, allowing for effective implantation and integration, maximizing the utility of donor bone material and enhancing treatment outcomes.
Implementation Method 1
The polymeric binder may promote cohesion between bone material with or without forming a bond between the polymer and the bone material
Implementation Method 2
a method involving centrifugation or isostatic pressure to create a strong, flexible composite
Implementation Method 3
a method involving centrifugation or isostatic pressure to create a strong, flexible composite
Data Source
AI summary
Embodiments of the present technology include a method of making a bone composite graft for administration to a patient. The method may include combining a human cadaveric bone material with a plurality of polymethyl methacrylate binder particles and spincasting the combined human cadaveric bone material and polymethyl methacrylate binder particles to produce the bone composite graft. The method may also include ablating the bone composite graft to increase the surface area of bone material exposed. The human cadaveric bone material may be immobilized in the plurality of polymethyl methacrylate binder particles. The human cadaveric bone material may be present in an amount that is 50 weight percent of the bone composite graft, or less. Additionally, the bone composite graft may have a yield strength that is at least 13,000 N/cm2 and no greater than 15,000 N/cm2.