Composite Bone Implant Merging Osteoinductive and Osteoconductive Functions
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current structural implants lack osteoconductive and osteoinductive capabilities for effective bone reconstruction and augmentation.
Innovation Solution
Combining allogenic bone material, such as demineralized bone matrix, with polylactic acid (PLA) and polyglycolic acid (PGA) isomers in scaffold configurations, including mesh or lattice structures, to create customizable implants that can be used for bone augmentation, stabilization, or defect reconstruction, potentially incorporating autologous bone grafts and bone morphogenic protein.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If separate bone graft materials are used independently, then each material has established efficacy for specific bone reconstruction applications, but no single implant provides both osteoconductive and osteoinductive capabilities simultaneously
Solution Approach 1:
The patent combines multiple bone graft materials (autologous bone, allogenic bone, demineralized bone matrix, and synthetic bone substitutes) into a single composite implant structure. This merging of materials provides both osteoconductive properties (from the scaffold structure and bone matrix) and osteoinductive properties (from growth factors and living bone cells), resolving the contradiction by making one implant perform multiple functions that previously required separate materials
Solution Approach 2:
The implant uses composite material construction where different bone graft materials are integrated together - autologous bone provides living cells and growth factors, allogenic bone provides structural framework, demineralized bone matrix provides osteoinductive factors, and synthetic materials provide structural support. This composite approach enables simultaneous osteoconduction and osteoinduction in a single implant
2Strength
If structural implants are used for bone stabilization, then mechanical support is provided, but the implants do not facilitate bone ingrowth or integration
Solution Approach 1:
The implant incorporates a porous or lattice scaffold structure that provides mechanical strength while allowing bone ingrowth. The porous architecture enables osteoconduction by facilitating bone cell migration and vascular infiltration, thus resolving the contradiction between providing structural support and enabling bone integration
Solution Approach 2:
The implant merges structural support functions with biological integration functions by incorporating both load-bearing scaffold materials and osteoinductive/osteoconductive materials. This combination allows the implant to simultaneously provide mechanical stabilization and facilitate active bone ingrowth, eliminating the need for separate structural and biological implants
3Duration of action of stationary object
If permanent implants are used for bone reconstruction, then structural support is maintained long-term, but future hardware removal is required
Solution Approach 1:
The implant uses resorbable materials that gradually degrade and are replaced by native bone tissue over time. The scaffold structure is temporarily supportive during healing but ultimately dissolves, eliminating the need for hardware removal. This resolves the contradiction by providing long-term support during the critical healing period while automatically discarding the implant once bone regeneration is complete
Data Source
AI summary
Aspects of the present invention provide implants for augmentation, stabilization, or defect reconstruction of bone tissue, comprising a scaffold portion structured to provide shape to the implant, the scaffold portion comprising one or more of the following: one or more polylactic acid isomer; one or more polyglycolic acid isomer; and/or allogenic bone material, or similar compound.