Composite Clay Toxin Binding System for Lipophilic Mycotoxins
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Solution Overview
Problem
Current toxin binding systems are ineffective in binding lipophilic mycotoxins, such as T-2 toxin, which cause severe oral lesions in animals, and do not inhibit the recirculation of toxins through saliva, leading to increased lesion severity.
Innovation Solution
A toxin binding system comprising novel combinations of organoclay, aluminosilicate clay, synthetic hectorite clay, and humic acid, which can be safely mixed into animal feed to bind mycotoxins, endotoxins, and pesticides in the gastrointestinal tract and mouth, effectively reducing bioavailability and associated toxicities.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If current toxin binders are used, then hydrophilic toxins can be bound in the gastrointestinal tract, but lipophilic toxins such as T-2 toxin cannot be bound and oral lesions are not prevented
Solution Approach 1:
The patent combines multiple clay materials with different binding properties - bentonite for hydrophilic toxins, organoclay for lipophilic toxins, and synthetic hectorite for enhanced binding capacity. This composite approach allows the binder to effectively bind both hydrophilic and lipophilic toxins simultaneously, resolving the limitation of single-material binders that could only target one toxin type.
Solution Approach 2:
The toxin binding composition is designed to perform multiple functions: binding hydrophilic toxins in the gastrointestinal tract, binding lipophilic toxins that cause oral lesions, and preventing toxin recirculation through saliva. This multi-functional design allows a single product to address multiple toxin-related problems that previously required separate interventions.
2Reliability
If clays are added to bind mycotoxins in the gastrointestinal tract, then mycotoxin bioavailability is decreased, but lipophilic toxins are not bound and recirculation through saliva continues
Solution Approach 1:
The patent uses a composite clay system where bentonite provides gastrointestinal binding, organoclay provides lipophilic toxin binding capacity, and synthetic hectorite enhances overall binding efficiency. This combination ensures toxins are bound in both the gastrointestinal tract and oral cavity, preventing recirculation and extending the effective duration of toxin neutralization.
Solution Approach 2:
The clay composition acts as an intermediary substance that intercepts toxins at multiple sites - in the gastrointestinal tract and in the oral cavity - preventing their absorption and recirculation. The clays serve as mediating agents that transform free toxins into bound complexes that can be safely excreted.
3Device complexity
If a single clay material is used to bind toxins, then the binding mechanism is simple, but the composition cannot bind both hydrophilic and lipophilic toxins effectively
Solution Approach 1:
The patent employs a composite material system combining bentonite, organoclay, and synthetic hectorite in specific proportions. Each component contributes different binding characteristics - bentonite for hydrophilic interactions, organoclay for lipophilic interactions, and synthetic hectorite for enhanced adsorption capacity - creating a synergistic effect that expands the binding range without excessive complexity.
Solution Approach 2:
Different clay components are distributed within the composition to provide localized binding properties - bentonite components target hydrophilic toxins, organoclay components target lipophilic toxins, and synthetic hectorite components provide enhanced binding throughout the gastrointestinal tract and oral cavity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system effectively binds a wide range of toxins, including lipophilic mycotoxins, reducing oral lesions and systemic toxicity, and is more effective than individual components when combined, as demonstrated by increased adsorption and desorption efficiency.
Implementation Method 1
these clays have been found to act as enterosorbents that tightly and selectively bind these poisons in the gastrointestinal tract of animals, decreasing their bioavailability and associated toxicities
Implementation Method 2
as demonstrated by increased adsorption and desorption efficiency
Data Source
AI summary
In some embodiments, a composition and/or method may include a toxin binding system formulated for safe and effective mixture into various feed rations which are fed to monogastric and ruminant animals such as poultry, swine, cows, cattle, and fish, among others. The toxin binding system includes novel combinations of one or more of an organoclay, an activated hydrated sodium calcium aluminosilicate clay, and a synthetic hectorite clay. In some embodiments, the binding composition may include organoclay, bentonite, hectorite, Leonardite, and/or any combination thereof. The toxin binding complex may effectively bind mycotoxins, endotoxins and some pesticides in the animal's digestive system, preventing their absorption and the consequent damages to the animal. This binding action includes the T-2 toxin, which can start their damaging action in the animal's mouth, hence, offering protection from oral lesions.