Composite Decellularized Matrix Membrane for Artificial Bladder
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Solution Overview
Problem
Current bladder surgery methods, such as radical total cystectomy, lead to complications like calculus formation, intestinal obstruction, and metabolic disorders, which significantly affect the quality of life and increase surgical risks for patients with muscle-invasive bladder cancer.
Innovation Solution
A composite decellularized matrix membrane is developed by wrapping a polymer membrane with two layers of decellularized matrix membranes, prepared from porcine small intestine, bladder, and skin, using materials like polycaprolactone, polylactic acid, and polyurethane, to prevent water infiltration and calculus formation, facilitating a more effective and less invasive artificial bladder solution.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If radical total cystectomy is performed to treat muscle-invasive bladder cancer, then survival rate is improved and recurrent metastasis is reduced, but surgical complexity increases and postoperative complications such as calculus formation, intestinal obstruction, and metabolic disorders occur
Solution Approach 1:
The invention segments the bladder replacement function into two distinct components: a polymer membrane providing waterproofing and structural integrity, and a decellularized matrix membrane providing biological compatibility and tissue regeneration. This segmentation allows each component to specialize in its function, reducing overall surgical complexity while maintaining reliability
Solution Approach 2:
The invention uses composite materials by combining synthetic polymer membrane with natural decellularized matrix membrane. The polymer membrane (made from materials like polyurethane, polycaprolactone, or polylactic acid) provides water impermeability and mechanical strength, while the decellularized matrix membrane provides biocompatibility and promotes tissue regeneration, thereby improving survival rate while reducing postoperative complications
2Reliability
If radical total cystectomy is performed to treat muscle-invasive bladder cancer, then recurrent metastasis is reduced, but postoperative complications such as calculus formation and inflammation increase
Solution Approach 1:
The decellularized matrix membrane acts as an intermediary layer between the synthetic polymer membrane and the patient's body tissues. This intermediary provides a biologically compatible interface that prevents direct contact between urine and the synthetic material, thereby eliminating the harmful effect of calculus formation while maintaining the anti-metastasis benefits of complete bladder removal
Solution Approach 2:
The invention changes the surface properties and chemical composition of the bladder replacement material by using decellularized matrix coating. This parameter change from pure synthetic material to composite material with natural extracellular matrix components prevents urine crystallization and calculus formation, while maintaining the therapeutic effect against recurrent metastasis
3Reliability
If radical total cystectomy is performed to treat muscle-invasive bladder cancer, then survival rate is improved, but recovery time increases and medical costs increase
Solution Approach 1:
The decellularized matrix membrane provides self-service functionality by actively promoting tissue regeneration and integration with the patient's own tissues. The natural extracellular matrix components attract and support cell migration, proliferation, and differentiation, enabling the construct to self-assemble and integrate with surrounding tissues, thereby reducing recovery time while maintaining the life-saving benefits of the surgery
4Reliability
If polymer membrane is used for artificial bladder construction, then water infiltration is prevented, but calculus formation occurs due to water accumulation
Solution Approach 1:
The decellularized matrix membrane serves as an intermediary layer between the waterproof polymer membrane and the urine environment. This intermediary layer allows controlled interaction between urine and the synthetic material, preventing direct water accumulation against the polymer surface that would lead to calculus formation, while the polymer membrane continues to provide effective water infiltration prevention
Data Source
AI summary
The present disclosure provides a composite decellularized matrix membrane and use thereof. The composite decellularized matrix membrane prepared by the present disclosure is prepared by wrapping one layer of a polymer membrane with two layers of decellularized matrix membranes. The decellularized matrix membrane is prepared from at least a biomaterial of a porcine small intestine, a porcine bladder, and porcine skin. The polymer membrane is prepared from at least a polymer material of polycaprolactone, polydimethylsiloxane, polyurethane, polylactic acid-glycolic acid, polyvinyl alcohol, and polyhydroxy fatty acid ester. The composite decellularized matrix membrane prepared by the present disclosure can prevent calculi, makes a patient suffer less, recover faster, live better, and cost less, while medical resources are saved, and hope for treatment is also brought for some patients with a contraindication to an in-situ ileal neobladder surgery.