Composite Vascular Substitute with Fish Collagen Coating
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Solution Overview
Problem
Current synthetic vascular substitutes fail to provide reliable long-term patency and healing in small-diameter vessels due to thrombosis, immune response, infection susceptibility, anastomotic hyperplasia, and compliance mismatch, especially in low-flow areas like coronary and crural arteries, with no effective synthetic substitutes available for these applications.
Innovation Solution
A composite vascular substitute with an inner resorbable collagen layer, a non-resorbable knitted fabric layer, and an outer resorbable collagen layer, using fish collagen from Czech carp, which is designed to mimic native blood vessel structure and properties, including a helical arrangement of collagen fibers to enhance mechanical response and reduce thrombogenicity, and is enriched with pharmacologically active substances for improved biocompatibility and infection resistance.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If synthetic materials like PET or ePTFE are used for large-diameter vessels, then mechanical strength and durability are improved, but long-term patency and biocompatibility deteriorate in small-diameter vessels
Solution Approach 1:
The invention uses a composite structure combining synthetic knitted fabric (providing mechanical strength) with biological collagen layers (providing biocompatibility and promoting endothelialization). This composite approach allows the prosthesis to simultaneously achieve the mechanical durability of synthetic materials and the biological compatibility of natural tissues, resolving the contradiction between strength and long-term patency in small-diameter vessels
Solution Approach 2:
Different layers of the prosthesis have different properties: the inner and outer collagen layers provide biocompatibility and cell attachment, while the middle knitted fabric layer provides mechanical strength. This local differentiation allows each layer to optimize its function, with the synthetic layer providing durability and the biological layers providing patency through endothelialization
2Reliability
If collagen is used as a coating material, then biocompatibility is improved, but mechanical strength and structural stability deteriorate
Solution Approach 1:
The prosthesis combines collagen (providing biocompatibility) with synthetic knitted fabric (providing mechanical strength). The collagen layers are applied as coatings on the synthetic substrate, creating a composite structure where each material contributes its advantageous properties without compromising the other
Solution Approach 2:
The collagen is concentrated in the inner and outer layers where biocompatibility is most needed (contact with blood and surrounding tissue), while the synthetic knitted fabric forms the middle structural layer providing mechanical support. This spatial distribution optimizes both biocompatibility and strength
3Stability of the object's composition
If non-resorbable synthetic materials are used, then structural stability is improved, but immune response and infection susceptibility increase
Solution Approach 1:
The prosthesis uses resorbable collagen on the inner and outer surfaces (where immune response occurs) and non-resorbable synthetic material in the middle layer (where structural stability is needed). The biological collagen layers reduce immune response and promote endothelialization, while the synthetic core maintains structural integrity
Solution Approach 2:
The collagen layers are applied beforehand to create a biocompatible surface that promotes endothelial cell attachment and growth before the prosthesis is implanted. This preliminary biological preparation reduces immune response and infection susceptibility from the outset
Data Source
AI summary
The present invention relates to a composite vascular substitute, in particular for flow rates under 100 ml/min and inner diameters under 6 mm, which contains a non-resorbable knitted fabric layer (2), which is provided on the inner and outer sides with a collagen compound coating of freshwater fish - Czech carp. The non-resorbable knitted fabric compound (2) is preferably placed on a self-supporting resorbable collagen compound layer (1), wherein the non-resorbable layer (2) is covered with an intermediate collagen compound layer (4) overlaid with an outer, resorbable collagen compound layer (3). Furthermore, it relates to the method for producing this vascular substitute, wherein the collagen compound with a collagen concentration of 4 to 12% by weight is kept at 15 to 30 °C for 18 to 30 hours, and then the non-resorbable knitted fabric layer 2 is integrated in one collagen compound layer to make a collagen compound coating on the inner and outer sides of the non-resorbable knitted fabric layer 2, or the collagen compound with a collagen concentration of 4 to 12% by weight is kept at 15 to 30 °C for 18 to 30 hours, and then the collagen compound is extruded to make the inner resorbable layer (1) in the form of a tube that is dried at the room temperature until pliable, and the inner resorbable layer (1) is overlaid with the non-resorbable knitted fabric layer (2), on which the outer resorbable layer (3) of collagen compound with a collagen concentration of 3 to 12% by weight is extruded, and the vascular substitutes are dried at 15 to 30 °C for 15 to 30 hours until pliable, and then the vascular substitutes are hardened with 1.5 to 3.2% resin for 3 to 10 minutes and then they are dried and softened up in a 15 to 30% glycerine bath for 15 to 25 minutes.