Composite Herbal Composition for Neurodegenerative Disease Treatment
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Solution Overview
Problem
Current treatments for neurodegenerative diseases, such as Riluzole and Yoo's Neurosolution, cause significant side effects and are not suitable for long-term administration, while bone marrow-derived adult stem cells are still in clinical trial phases, necessitating a non-cytotoxic, side-effect-free alternative for alleviating neuroinflammation and protecting neural cells.
Innovation Solution
A composition comprising Curcumae longae rhizome, Gastrodiae rhizoma, Polygalae radix, Salviae radix, Chaenomeles fructus, Paeoniae radix, Glycyrrhizae radix, Atractylodis rhizoma, and Pulvis aconiti tuberis purificatum is prepared through extraction and concentration using ethanol, followed by filtration and drying, to create a mixture extract that reduces pain and inflammation without cytotoxicity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional agents like Riluzole are used to treat neurodegenerative diseases, then the disease progression is slowed, but side effects such as decreased liver function, dizziness, diarrhea, abdominal pain, vomiting, and loss of appetite occur
Solution Approach 1:
The patent uses a composite herbal formulation containing multiple traditional Korean medicine ingredients (Ginseng, Poria, Atractylodes, Cinnamon, etc.) working synergistically to treat neurodegenerative diseases. This composite approach provides therapeutic effectiveness while reducing the harmful side effects associated with conventional single-agent treatments like Riluzole.
2Duration of action of moving object
If Riluzole is administered long-term, then disease management continues, but the treatment must be stopped in about 14% of patients due to side effects
Solution Approach 1:
The herbal composition is designed to be naturally tolerable and self-sustaining for long-term use without causing the side effects that force discontinuation of conventional treatments. The natural ingredients work synergistically to maintain therapeutic effectiveness throughout prolonged administration periods.
3Reliability
If Yoo's Neurosolution containing ursodeoxycholic acid is used to treat motor neuron disease, then brain cell death is inhibited, but side effects such as vomiting, abdominal pain, diarrhea, dizziness, headache, difficulty in breathing, and nausea occur
Solution Approach 1:
The patent employs a composite herbal formulation with multiple traditional Korean medicine ingredients that work synergistically to protect neural cells and inhibit brain cell death. This natural composite approach achieves neuroprotection while avoiding the severe side effects associated with ursodeoxycholic acid-based treatments.
4Reliability
If bone marrow-derived adult stem cells are used for treatment, then neurodegenerative diseases are targeted, but the therapy is still in clinical trial phases and requires many years of studies before commercialization
Solution Approach 1:
The patent utilizes traditional Korean herbal medicines that are readily available, cost-effective, and do not require lengthy clinical trial periods. These natural ingredients can be immediately formulated and deployed as a therapeutic composition, avoiding the decades-long development timeline associated with stem cell therapies.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively alleviates neuroinflammation, protects neural cells, and reduces pain in neurodegenerative diseases without causing side effects, making it suitable for long-term administration.
Implementation Method 1
extracting the mixture to obtain a mixture extract
Implementation Method 2
concentrating the mixture extract
Implementation Method 3
drying the mixture extract
Data Source
AI summary
Disclosed herein is a pharmaceutical composition for preventing, alleviating or treating neurodegenerative diseases. The pharmaceutical composition contains, as active ingredients, Curcumae longae rhizome, Gastrodiae rhizoma, Polygalae radix, Salviae radix, Chaenomeles fructus, Paeoniae radix, Glycyrrhizae radix, Atractylodis rhizome, and Pulvis aconiti tuberis purificatum. The pharmaceutical composition is prepared by a method including the steps of: mixing Curcumae longae rhizome, Gastrodiae rhizoma, Polygalae radix, Salviae radix, Chaenomeles fructus, Paeoniae radix, Glycyrrhizae radix, Atractylodis rhizome, and Pulvis aconiti tuberis purificatum to obtain a mixture, and extracting the mixture to obtain a mixture extract; filtering the mixture extract; concentrating the mixture extract; and drying the mixture extract.