Composite Light Adjustable Intraocular Lens Adhesion Promoter
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Solution Overview
Problem
Current intraocular lenses (IOLs) face challenges such as uneven healing processes, misalignment, and imperfect modeling post-surgery, leading to suboptimal medical outcomes, despite advancements in cataract surgery techniques and materials like soft acrylate and silicone-based polymers.
Innovation Solution
A composite light adjustable intraocular lens (CLA IOL) is developed, combining the benefits of acrylate and light adjustable lenses, featuring a silicone-based light adjustable lens attached to an acrylic IOL with integrated haptics, allowing for post-surgical adjustments via illumination to correct misalignments and optical power modifications.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If a light adjustable lens is used to enable post-surgical adjustments, then optical performance and alignment precision are improved, but device complexity and manufacturing difficulty increase
Solution Approach 1:
The patent combines a silicone-based light adjustable lens with an acrylic intraocular lens to create a composite structure. The acrylic IOL provides structural stability and ease of implantation, while the silicone light adjustable lens enables post-surgical optical power adjustment through light-induced shape change, thus achieving both precision and manageability
Solution Approach 2:
The intraocular lens is divided into two distinct components: a fixed acrylic IOL portion and an adjustable silicone light adjustable lens portion. This segmentation allows each component to fulfill its specific function independently while working together as a unified system
2Adaptability or versatility
If a silicone-based light adjustable lens is attached to an acrylic IOL, then adaptability and adjustability are improved, but ease of manufacture deteriorates
Solution Approach 1:
The light adjustable lens is pre-attached to the acrylic intraocular lens during manufacturing using an adhesion promoter. This preliminary bonding action simplifies the implantation process by eliminating the need for separate attachment steps and ensures proper alignment before the device enters the patient's eye
3Reliability
If an adhesion promoter is used to attach the light adjustable lens to the IOL, then reliability of attachment is improved, but device complexity increases
Solution Approach 1:
An adhesion promoter serves as a chemical intermediary between the silicone-based light adjustable lens and the acrylic intraocular lens. This intermediary substance facilitates strong bonding between the two dissimilar materials, ensuring reliable attachment while allowing each component to maintain its inherent properties
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The CLA IOL improves surgical control and predictability during cataract surgery, reduces misalignment issues, and enhances optical performance by enabling precise adjustments post-surgery, thereby improving patient outcomes and expanding market acceptance of advanced IOLs.
Implementation Method 1
The adhesion promoter can include a first orthogonal functional group, configured to bond with an acrylic component of the acrylic intraocular insert; and a second orthogonal functional group, configured to bond with a silicone component of the silicone-based light adjustable lens
Implementation Method 2
These lenses involve light sensitive materials that photopolymerize upon activation by an irradiation. Irradiation with a carefully designed radial profile initiates the photopolymerization with a corresponding radial profile, which, in turn, leads to the IOL changing its physical shape and therefore, its optical power
Data Source
AI summary
A composite light adjustable intraocular lens can include an acrylic intraocular insert; a silicone-based light adjustable lens, attached to the acrylic intraocular insert with an adhesion promoter; and haptics; wherein the adhesion promoter includes a first orthogonal functional group, configured to bond with an acrylic component of the acrylic intraocular insert; and a second orthogonal functional group, configured to bond with a silicone component of the silicone-based light adjustable lens.