Composite Particles with High Inorganic Nanoparticle Content

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Solution Overview

Problem

Conventional magnetic particles face challenges in balancing biochemical substance binding capacity with magnetic separation performance, particularly with small particle sizes exhibiting poor magnetic collection and dispersion in liquids.

Innovation Solution

Composite particles with a high content of inorganic nanoparticles (>80% by mass) and a controlled particle size (10-1000 nm) are developed, incorporating organic polymers and surface modifications to enhance magnetic separation efficiency and prevent agglomeration, allowing for effective magnetic separation even at small sizes.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If magnetic particles have a small particle size, then the surface area per unit mass increases and binding capacity for biochemical substances improves, but magnetic separation performance deteriorates

Engineering Contradiction:

Improvebinding capacity for biochemical substancesVSAvoidmagnetic separation speed

Core Design Contradiction:

Quantity of substanceVSSpeed

Solution Approach 1:

The patent changes the magnetic substance content parameter from conventional low levels to a high content of more than 80% by mass. This parameter change enables small particles (10-1000 nm) to achieve both high binding capacity and excellent magnetic separation performance, resolving the contradiction between particle size and magnetic separation speed.

Inventive Principle:

Principle #35Parameter changes

2Speed

If magnetic particles have a large particle size, then magnetic separation performance improves, but the amount of biochemical substance bound per unit mass decreases

Engineering Contradiction:

Improvemagnetic separation speedVSAvoidbinding capacity for biochemical substances

Core Design Contradiction:

SpeedVSQuantity of substance

Solution Approach 1:

The patent increases the magnetic substance content to more than 80% by mass, which fundamentally changes the magnetic properties of the particles. This allows small particles to achieve magnetic separation performance previously only attainable with large particles, while maintaining high surface area for biochemical binding.

Inventive Principle:

Principle #35Parameter changes

3Ease of manufacture

If conventional magnetic particles with low magnetic substance content are used, then production cost is reduced, but magnetic collection performance deteriorates

Engineering Contradiction:

Improveproduction costVSAvoidmagnetic collection performance

Core Design Contradiction:

Ease of manufactureVSReliability

Solution Approach 1:

The patent creates composite particles consisting of an organic polymer matrix combined with inorganic magnetic nanoparticles (more than 80% by mass). This composite structure achieves high magnetic collection performance while maintaining ease of production through established composite material synthesis methods.

Inventive Principle:

Principle #40Composite materials

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composite particles achieve excellent magnetic separation performance while maintaining a high binding capacity for biochemical substances, balancing the need for efficient separation and reactivity.

Implementation Method 1

magnetic particles having a small particle size are characterized in that they have a large surface area per unit mass, and thus capable of binding a large amount of biochemical substance

Methodology Applied

Scientific EffectMagnetism: Magnetism

Implementation Method 2

the composite particles having a high content of inorganic nanoparticles, such as particles of a magnetic substance

Methodology Applied

Scientific EffectSuperparamagnetism: Superparamagnetism

Implementation Method 3

the composite particles having, for example, the following constitutions, allow for solving these problems

Methodology Applied

Scientific EffectAdsorption: Adsorption

Implementation Method 4

Composite particles each including an organic polymer and inorganic nanoparticles

Methodology Applied

Scientific EffectPolymer matrix binding: Adhesive

Implementation Method 5

incorporating organic polymers and surface modifications to enhance magnetic separation efficiency and prevent agglomeration

Methodology Applied

Scientific EffectSurface tension: Surface Tension

Implementation Method 6

the composite particles include at least one selected from the group consisting of a surfactant, an acid group-containing compound, an amino group-containing compound

Methodology Applied

Scientific EffectSurfactant action: Surfactant

Data Source

PatentUS11237162B2Composite particles, coated particles, method for producing composite particles, ligand-containing solid phase carrier and method for detecting or separating target substance in sample

Publication Date: 2022.02.01 JSR CORPORATION

AI summary

The present invention relates to composite particles, coated particles, a method of producing composite particles, a ligand-containing solid phase carrier, and a method of detecting or separating a target substance in a sample. The above described composite particles each contains an organic polymer and inorganic nanoparticles, wherein the content of the inorganic nanoparticles in the composite particles is more than 80% by mass, and wherein the composite particles have a volume average particle size of from 10 to 1,000 nm.