Composite Peptide Collagen Stimulators for Skin Aging

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Solution Overview

Problem

There is a need for agents that stimulate procollagen and collagen production in human skin to improve skin appearance and address signs of aging such as wrinkles, sagging, and thinning skin.

Innovation Solution

Cosmetic formulations containing specific compounds with a 3-6 membered heterocyclic ring structure that stimulate procollagen and collagen production when topically applied, often combined with retinoids and alpha- or beta-hydroxy acids, to enhance skin texture and reduce signs of aging.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If topical agents are applied to stimulate collagen production, then skin appearance and structure are improved, but the effectiveness and stability of these agents are insufficient

Engineering Contradiction:

Improveeffectiveness and stability of collagen-stimulating agentsVSAvoidcollagen production stimulation

Core Design Contradiction:

ReliabilityVSProductivity

Solution Approach 1:

The patent employs composite peptide structures combining hydrophobic domains (for membrane insertion and stability) with hydrophilic collagen-mimetic domains (for bioactivity). This composite design creates compounds that are both stable in formulation and effective at stimulating collagen production, resolving the contradiction between reliability and productivity.

Inventive Principle:

Principle #40Composite materials

Solution Approach 2:

The patent systematically varies peptide parameters including amino acid composition, chain length, hydrophobicity, and secondary structure content to optimize both stability and collagen-stimulating activity. By adjusting these parameters, the invention achieves compounds with improved reliability while maintaining high productivity in collagen stimulation.

Inventive Principle:

Principle #35Parameter changes

2Strength

If procollagen and collagen production is increased, then skin thickness and firmness are improved, but signs of aging such as wrinkles, sagging, and thinning skin persist

Engineering Contradiction:

Improveskin firmness and thicknessVSAvoidwrinkles, sagging, and thinning skin

Core Design Contradiction:

StrengthVSObject-affected harmful factors

Solution Approach 1:

The patent converts the natural aging process and UV-induced damage into beneficial effects by using peptides that stimulate compensatory collagen production. The peptides harness cellular responses to stress and damage, transforming harmful aging factors into opportunities for renewed collagen synthesis and skin rejuvenation.

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

Solution Approach 2:

The patent applies collagen-mimetic peptides in advance to prevent and treat signs of aging before they become severe. By continuously stimulating procollagen conversion and collagen production, the peptides maintain skin firmness and thickness proactively, preventing wrinkles and sagging rather than merely addressing them after occurrence.

Inventive Principle:

Principle #10Preliminary action

Data Source

PatentUS9283163B2Collagen stimulators and their use in the treatment of skin

Publication Date: 2016.03.15 AVON PROD INC

AI summary

Methods for preventing, ameliorating, or reducing dermatological signs of aging are provided which employ cosmetic composition comprising novel active agents that enhance collagen production in the skin.