Composite Phyto-Extract Anti-Inflammatory Composition
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Solution Overview
Problem
Current anti-inflammatory substances, both natural and synthetic, often cause significant side effects, and there is a need for a substance with excellent anti-inflammatory activity that is safe for human use.
Innovation Solution
An anti-inflammatory composition comprising a phyto-extract mixture including Perilla frutescens Britt. extract and Atractylodes japonica Koidz. extract, which can be used to treat inflammatory diseases, is developed, with the extracts being obtained through methods such as lyophilization and supercritical extraction to enhance their anti-inflammatory efficacy.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If natural and synthetic corticosteroid agents are used as anti-inflammatory substances, then anti-inflammatory activity is improved, but side effects worsen (increased blood pressure, salt and water stagnation, kidney damage, and increased potassium and calcium secretion)
Solution Approach 1:
The patent extracts and utilizes specific active components (isoegomaketone from Perilla frutescens and atlactylenolide from Atractylodes japonica) from natural plant sources to create an anti-inflammatory composition that achieves therapeutic effects without the harmful side effects associated with synthetic corticosteroids
Solution Approach 2:
The patent combines multiple natural plant extracts (Perilla frutescens and Atractylodes japonica) in specific ratios to create a composite phyto-extract mixture that synergistically enhances anti-inflammatory activity while maintaining safety and reducing toxicity compared to single-substance treatments
2Reliability
If NSAIDs such as acetylsalicylic acid are used as anti-inflammatory substances, then anti-inflammatory activity is improved, but side effects worsen (respiratory stimulation, circulatory collapse, upper abdominal pain, vomiting, gastrointestinal bleeding, liver damage, platelet inhibition)
Solution Approach 1:
The patent extracts beneficial anti-inflammatory compounds from natural plant sources (isoegomaketone and atlactylenolide) to replace synthetic NSAIDs, achieving similar therapeutic effects without the severe gastrointestinal, hepatic, and cardiovascular side effects associated with conventional NSAID therapy
Solution Approach 2:
The patent utilizes naturally occurring plant compounds that can be sustainably harvested and regenerated, providing a renewable alternative to synthetic pharmaceuticals with cumulative toxic effects, thereby offering a safer long-term treatment option
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively treats and prevents inflammation with reduced toxicity, offering a safe and effective alternative for various applications, including cosmetics, health functional foods, and medicines, by leveraging the anti-inflammatory properties of isoegomaketone and atlactylenolide.
Implementation Method 1
The composition effectively treats and prevents inflammation with reduced toxicity, offering a safe and effective alternative for various applications, including cosmetics, health functional foods, and medicines, by leveraging the anti-inflammatory properties of isoegomaketone and atlactylenolide
Data Source
AI summary
The present invention relates to an anti-inflammatory composition and a composition for treatment of an inflammatory disease, both comprising a composite plant extract and, more particularly, to an anti-inflammatory composition comprising a composite plant extract including a Perilla frutescens extract and an Atractylodes macrocephala Koidzumi extract; a preparation method thereof; and a pharmaceutical composition comprising the composite extract for treatment of an inflammatory disease.