Composite Probiotic Strain Blend for Constipation Relief
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Solution Overview
Problem
Existing probiotic interventions for constipation are inadequate in addressing slow intestinal peristalsis and microecological imbalance, leading to ineffective relief of constipation symptoms.
Innovation Solution
A composite probiotic formulation comprising Bifidobacterium animalis subsp. lactis BLa36, Lactobacillus rhamnosus LRa05, Bacillus coagulans BC99, and Bifidobacterium bifidum BBi32 strains, compounded at specific ratios, to synergistically promote intestinal peristalsis and increase gastrointestinal peptides and short-chain fatty acids.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a single probiotic strain is used to treat constipation, then the intervention is simple and safe, but the effectiveness in promoting intestinal peristalsis and relieving constipation symptoms is insufficient
Solution Approach 1:
The patent combines four different probiotic strains (Bifidobacterium animalis subsp. lactis BLa36, Lactobacillus rhamnosus LRa05, Bacillus coagulans BC99, and Bifidobacterium bifidum BBi32) into a composite probiotic formulation. This merging of multiple strains with different functional characteristics creates a synergistic effect that enhances intestinal peristalsis promotion and constipation relief compared to single-strain interventions, while maintaining the safety profile of probiotic use.
Solution Approach 2:
The patent creates a composite probiotic product by formulating a specific combination of four probiotic strains in defined ratios. This composite formulation leverages the complementary benefits of each strain - including peptide production, short-chain fatty acid generation, and direct peristalsis stimulation - to achieve enhanced therapeutic effectiveness for constipation management.
2Productivity
If multiple probiotic strains are compounded to enhance effectiveness, then the relief of constipation symptoms is significantly improved, but the formulation complexity increases
Solution Approach 1:
The patent merges four probiotic strains into a single composite formulation with defined ratios, achieving synergistic effects that significantly improve constipation relief. The merging approach consolidates multiple functional mechanisms (peptide production, short-chain fatty acid generation, direct peristalsis stimulation) into one integrated product that addresses the limitations of single-strain interventions.
3Reliability
If probiotics are used to restore gut microbiota balance, then the microecological imbalance is corrected, but the mechanism alone is insufficient to effectively promote intestinal peristalsis
Solution Approach 1:
The patent combines multiple probiotic strains that collectively address both gut microbiota restoration and direct peristalsis promotion. The formulation includes strains capable of producing gastrointestinal peptides (motilin, substance P, vasoactive intestinal peptide) and short-chain fatty acids, in addition to restoring microbial balance, thereby achieving dual benefits that neither single-strain nor microbiota-restoration-only approaches can accomplish.
Solution Approach 2:
The patent changes the functional parameters of the probiotic intervention by selecting strains with specific metabolic capabilities - particularly those that produce gastrointestinal peptides and short-chain fatty acids. This parameter change approach ensures the probiotic formulation not only restores microbial balance but also actively promotes intestinal peristalsis through biochemical mechanisms.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composite probiotic significantly enhances intestinal propulsion rates, increases gastrointestinal peptide levels, and elevates short-chain fatty acid levels, effectively alleviating constipation symptoms and restoring intestinal health.
Implementation Method 1
probiotics in the human colon can digest soluble dietary fiber to produce short-chain fatty acids, further promoting intestinal peristalsis
Implementation Method 2
Probiotics have the functions of maintaining a balance in the gut microbiota, promoting intestinal peristalsis, and improving constipation
Data Source
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AI summary
Provided are a composite probiotic for improving constipation and a use thereof. The composite probiotic for improving constipation is composed of a Bifidobacterium animalis subsp. lactis BLa36 strain deposited under CGMCC No. 24029, a Lactobacillus rhamnosus LRa05 strain deposited under CGMCC No. 24377, a Bacillus coagulans BC99 strain deposited under CGMCC No. 19487, and a Bifidobacterium bifidum BBi32 strain deposited under CGMCC No. 16923. The four strains have a synergistic effect in relieving constipation symptoms.