Composite Resin Molded Body Sustained Release
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Solution Overview
Problem
Existing sustained-release agents face challenges in maintaining high rigidity and controlled release of medicinal agents in humid environments, with current methods either releasing the agent too quickly or limiting durability and application.
Innovation Solution
A composite resin molded body comprising a base resin and fibrous fillers with a volatile medicinal agent, where the fibrous fillers are coated with a hydrolyzable coating resin and exposed on the surface, promoting sustained release through water absorption and contact points, while maintaining high elastic modulus.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of stationary object
If a medicinal agent component is dispersed in a degradable polymer, then the medicinal agent can be released over time through polymer decomposition, but the rigidity required for structural application is compromised
Solution Approach 1:
The invention uses a composite structure combining a porous base material (for sustained release) with a separate polymer coating layer (for structural integrity). This allows the medicinal agent to be carried on the porous substrate while the coating provides the necessary rigidity and mechanical strength for structural applications.
Solution Approach 2:
The sustained-release agent is divided into two functional segments: a porous base material that provides the sustained release function and a polymer coating that provides structural strength. This segmentation allows each component to optimize its specific function without compromising the other.
2Strength
If porous particles are coated with a polymer to provide structural strength, then rigidity is improved, but the polymer coating may prevent effective medicinal agent release
Solution Approach 1:
The polymer coating is designed with specific parameters including controlled thickness, porosity, and hydrolyzability to balance structural strength and medicinal agent release. By adjusting these parameters, the coating provides rigidity while allowing controlled diffusion of the medicinal agent through its porous structure.
Solution Approach 2:
Both the base material and the polymer coating are designed with porous structures. The porous coating allows medicinal agent diffusion while maintaining structural integrity, solving the contradiction between preventing premature release and enabling controlled release.
3Reliability
If the polymer coating is made thick to improve durability, then structural strength increases, but the medicinal agent release time is extended beyond the desired period
Solution Approach 1:
The coating thickness and porosity are optimized to achieve the desired balance between durability and release period. A thinner, more porous coating provides adequate protection while allowing faster release, whereas a thicker, less porous coating extends durability but slows release.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composite resin molded body achieves high elastic modulus and sustained release of medicinal agents in humid environments, ensuring prolonged efficacy and structural integrity.
Implementation Method 1
at least a part of a surface of each of the plurality of fibrous fillers is coated with a hydrolyzable coating resin
Implementation Method 2
coated with a hydrolyzable coating resin
Implementation Method 3
a plurality of fibrous fillers each contain a volatile medicinal agent
Data Source
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AI summary
A composite resin molded body containing: a base resin; and a plurality of fibrous fillers dispersed in the base resin, wherein the plurality of fibrous fillers each contain a volatile medicinal agent, when the composite resin molded body is 100 mass%, a content of the plurality of fibrous fillers each containing the medicinal agent in the composite resin molded body is 10 mass% or more and 99 mass% or less, a part of each of at least one of the plurality of fibrous fillers is exposed on a surface of the composite resin molded body, and at least a part of a surface of each of the plurality of fibrous fillers is coated with a hydrolyzable coating resin.