Composite Tissue Image with Real-Time Adjustable Boundary
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Solution Overview
Problem
Conventional digital pathology systems face challenges in efficiently comparing and analyzing tissue samples from multiple slides stained with different assays, as they lack tools to navigate and align matching regions across slides, limiting the comprehensive analysis of tissue properties.
Innovation Solution
The system provides a computer-implemented method for creating a composite digital image from multiple digital images of adjacent tissue sections, using both local and global registration techniques to align and overlay images from different stains and imaging modes, allowing interactive adjustment of image regions and proportions, enabling a fused-view display.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Loss of information
If multiple digital images from different stains and imaging modes are combined for comprehensive tissue analysis, then the diagnostic information completeness is improved, but the image alignment and integration complexity increases
Solution Approach 1:
The system divides the composite image into multiple adjustable regions, each displaying image data from different slides or imaging modes. This segmentation allows independent control and optimization of each region while maintaining overall integration, reducing the complexity of managing multiple images as a single unit.
Solution Approach 2:
The patent employs registration techniques as intermediary processes to align and coordinate multiple digital images before integration. These registration algorithms serve as mediators that automatically match corresponding tissue structures across different stains and imaging modes, eliminating manual alignment complexity.
2Ease of operation
If interactive region adjustment is enabled for flexible image comparison, then the ease of operation is improved, but the processing time increases
Solution Approach 1:
The system performs preliminary global registration of all input images before interactive adjustment begins. This pre-alignment establishes a coordinated framework that enables rapid interactive region modifications without requiring recalculation of entire image registrations, significantly reducing processing time during user interaction.
Solution Approach 2:
The composite image interface allows dynamic, real-time adjustment of region boundaries and sizes during viewing. Users can interactively modify which portions of different slides appear in each region without reprocessing the entire image set, enabling flexible comparison while maintaining efficient performance through selective updates.
Data Source
AI summary
The disclosure relates to devices, systems and methods for generating a digital image of a tissue section that is a composite of two or more source digital images of adjacent tissue sections and which may have a real-time adjustable boundary between different source images. The devices include computer software products for a fused-view visualization tool which permits one or more of generating and displaying the composite image and modifying the location of one or more boundaries between source images comprising the composite image. The systems include computer-implemented systems such as work stations and networked computers for analyzing tissue samples using the fused-view visualization tool. The methods include processes for visualization of a tissue sample as a composite image derived from two or more slides of adjacent tissue sections, for example as an interactive composite image wherein the proportion of each source image in the composite image may be altered.