Composite Tissue Matrices for Strength and Suture Retention
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Solution Overview
Problem
Current acellular tissue matrix products lack sufficient structural integrity, tensile strength, burst strength, and suture retention strength for applications such as breast reconstruction and breast augmentation, and may not provide optimal compressive elasticity and mechanical properties for soft-tissue defects.
Innovation Solution
Combining intact acellular tissue matrices with porous acellular tissue matrix sponges, such as adipose tissue matrices, to create composite structures that leverage the biologic and mechanical properties of each component for improved regenerative and structural support.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If single-tissue matrix products are used, then the product structure is simple and easy to manufacture, but the mechanical strength and structural integrity are insufficient
Solution Approach 1:
The patent combines two different tissue matrix materials into a single composite product. The first material provides structural integrity and tensile strength, while the second material contributes compressive elasticity and porosity. This merging of materials resolves the contradiction by achieving superior mechanical properties without requiring complex multi-component assembly structures.
Solution Approach 2:
The invention uses composite tissue matrix materials where at least two different tissue types are integrated into a single product. This composite approach allows the product to simultaneously exhibit tensile strength from one material and compressive elasticity from another, directly addressing the strength limitation while maintaining manufacturing simplicity through a unified composite structure.
2Strength
If single-tissue matrix products are used, then the manufacturing process is simple, but the burst strength and suture retention strength are insufficient
Solution Approach 1:
The patent merges two tissue matrix materials in a co-manufacturing process where both materials are processed and integrated simultaneously. This approach achieves enhanced burst strength and suture retention through the combined properties of the materials while avoiding the need for separate assembly steps that would complicate manufacturing.
3Strength
If single-tissue matrix products are used, then the product design is simple, but the compressive elasticity and mechanical properties are insufficient for soft-tissue defects
Solution Approach 1:
The invention employs composite materials where one tissue matrix type contributes compressive elasticity and another provides structural support. This composite composition enables the product to meet the mechanical property requirements for soft-tissue defect repair while maintaining a relatively simple two-material structure that does not require complex multi-layered or modular designs.
4Reliability
If multiple tissue types are combined, then the mechanical support and biological properties are enhanced, but the product complexity increases
Solution Approach 1:
The patent merges multiple tissue types into a unified composite structure where the materials are integrated at the molecular and structural levels. This merging approach enhances mechanical support and biological functionality while avoiding the complexity of assembling separate components, as the multi-tissue structure is created as a single integrated product during manufacturing.
Data Source
AI summary
The present disclosure provides tissue products produced from extracellular tissue matrices. The tissue products can include acellular extracellular matrices including combinations of different tissue types. The combination can harness various properties of the different tissues to provide improved composite structures with desired mechanical and/or biologic properties.