Composite Tissue Matrix Structure for Porosity and Mechanical Stability
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Solution Overview
Problem
Existing tissue products, such as acellular tissue matrices and synthetic materials, often lack optimal mechanical properties, leading to issues like excessive compression, deformation, or insufficient tensile strength, which can compromise their effectiveness as tissue fillers and regenerative scaffolds.
Innovation Solution
The development of tissue products with a composite structure comprising a collagen-containing matrix embedded in a lattice framework, where higher-modulus regions are dispersed throughout, providing controlled mechanical properties and supporting cellular ingrowth and tissue regeneration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-generated harmful factors
If tissue products use acellular tissue matrices or synthetic materials with high porosity to facilitate cellular ingrowth, then cellular ingrowth and tissue regeneration are improved, but mechanical strength and resistance to compression deteriorate
Solution Approach 1:
The patent combines acellular tissue matrix with synthetic porous material to create a composite structure where the synthetic material provides mechanical strength and the tissue matrix provides biological functionality for cellular ingrowth
Solution Approach 2:
The tissue matrix is applied selectively in specific regions (e.g., outer layers or surface regions) where cellular ingrowth is most needed, while inner regions rely on the synthetic material for structural support
2Object-generated harmful factors
If tissue products are made with high porosity to allow cellular infiltration, then tissue regeneration is enhanced, but tensile strength and structural stability worsen
Solution Approach 1:
The composite structure combines the regenerative properties of tissue matrix with the structural stability of synthetic porous material, allowing both high porosity for cell infiltration and adequate tensile strength
Solution Approach 2:
The synthetic porous material provides a stable framework with controlled porosity that maintains structural integrity while allowing cellular infiltration and tissue regeneration
3Ease of operation
If tissue products use soft materials to provide favorable feel and aesthetic appearance, then patient comfort is improved, but volume retention and resistance to external compression deteriorate
Solution Approach 1:
The composite combines soft tissue matrix for patient comfort with stiffer synthetic material for volume retention and compression resistance
Solution Approach 2:
The softer tissue matrix is positioned in regions where patient comfort is prioritized, while the stiffer synthetic material provides structural support for volume retention
4Strength
If tissue products are made with high fiber density to increase mechanical strength, then tensile strength is improved, but cellular ingrowth capability deteriorates
Solution Approach 1:
The synthetic high-density material provides tensile strength while the tissue matrix layer provides pathways for cellular ingrowth
Solution Approach 2:
High fiber density is concentrated in regions requiring mechanical strength, while regions requiring cellular ingrowth have lower density or are covered with tissue matrix
Data Source
AI summary
The present disclosure provides tissue products produced from extracellular tissue matrices. The tissue products can include acellular extracellular matrices that have been treated in select areas to increase the compressive modulus of the matrix in the selected area while maintaining the ability to support cell growth and tissue regeneration. In addition, the tissue products can include collagen-containing materials that support tissue ingrowth along with a framework of collagenous or polymeric materials such that the combination has a desired compressive or tensile modulus and/or strength while maintaining the ability to support cell growth and tissue regeneration.