Compound Probiotic Strains for Synergistic Calcium Absorption

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Solution Overview

Problem

Existing probiotic strategies are inadequate for effectively promoting calcium absorption, which is crucial for bone health and overall mineral metabolism, and there is a need for improved probiotic preparations to address insufficient calcium absorption and its associated health issues.

Innovation Solution

A probiotic preparation combining Akkermansia muciniphila Akk11 and Bifidobacterium breve BBr16 strains synergistically enhances calcium absorption by improving intestinal health and absorption capacity, restoring normal electrolyte levels, and reducing bone calcium loss.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If single probiotic strain is used, then safety is maintained, but calcium absorption promotion effect is insufficient

Engineering Contradiction:

ImprovesafetyVSAvoidcalcium absorption promotion effect

Core Design Contradiction:

ReliabilityVSProductivity

Solution Approach 1:

The patent combines two probiotic strains (Akkermansia muciniphila and Bifidobacterium breve) into a compound preparation. The synergistic effect between the two strains enhances calcium absorption promotion while maintaining the safety of individual probiotic strains, resolving the contradiction between using single strain safety and multi-strain effectiveness.

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The patent creates a composite probiotic preparation containing multiple bacterial strains with different functions. Akkermansia muciniphila improves intestinal barrier function while Bifidobacterium breve enhances mineral absorption, and their combination produces a synergistic effect greater than the sum of individual effects, addressing the limitation of single-strain preparations.

Inventive Principle:

Principle #40Composite materials

2Productivity

If probiotic compounding is implemented, then calcium absorption effect is enhanced, but preparation complexity increases

Engineering Contradiction:

Improvecalcium absorption promotion effectVSAvoidpreparation complexity

Core Design Contradiction:

ProductivityVSDevice complexity

Solution Approach 1:

The patent merges two probiotic strains into a single compound preparation with a defined ratio (1:10 to 10:1 of Akkermansia to Bifidobacterium). This merging approach enhances effectiveness while providing a clear formulation guideline that simplifies the compounding process, balancing improved calcium absorption with manageable preparation complexity.

Inventive Principle:

Principle #5Merging (Combining)

Data Source

PatentUS20260109939A1Probiotic preparation containing akk11 strain for promoting calcium absorption and use thereof

Publication Date: 2026.04.23 JIANGSU WECARE BIOTECHNOLOGY CO LTD

AI summary

Provided are a probiotic preparation containing an Akk11 strain for promoting calcium absorption and a use thereof, and the probiotic preparation for promoting calcium absorption includes an Akkermansia muciniphila Akk11 strain and a Bifidobacterium breve BBr16 strain. The present application developed a novel compounding method for probiotics, and found potential interactions between the Akk11 strain and BBr16 strain that these two strains can cooperate with each other to synergistically enhance the effect of promoting calcium absorption, specifically manifested in: the overall metabolism ability of calcium can be improved through the improvement of intestinal health and the enhancement of the absorption capacity of the intestinal wall; the serum calcium level and phosphorus content can be promoted and restore a normal electrolyte level; and the loss of calcium in bones can be effectively reduced, thereby stabilizing the structure and function of the bones.