Compounding Manifold with Isolated Channels for Accurate Fluid Transfer
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Solution Overview
Problem
Compounding devices face inefficiencies in setup time, downtime during ingredient replacement, and accuracy at small volumes, with challenges in maintaining aseptic conditions and preventing errors in fluid transfer and path connections.
Innovation Solution
A compounding device system featuring a manifold with separate fluid channels and a transfer set design that includes primary and secondary intake ports, valves, and flexible output lines to prevent mixing and ensure accurate delivery, along with a user-friendly interface and improved cleaning features.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If a single fluid channel is used in the manifold, then the device complexity is reduced, but different ingredients cannot be delivered simultaneously without mixing
Solution Approach 1:
The manifold is segmented into multiple separate fluid channels (first channel, second channel, third channel) that are in fluid isolation from each other. Each channel can independently deliver different ingredients simultaneously without mixing within the manifold, enabling versatile multi-ingredient compounding while maintaining a relatively simple overall structure.
2Measurement precision
If multiple valves are used to control different ingredients, then the precision of ingredient delivery is improved, but the device complexity increases
Solution Approach 1:
Different valve configurations are applied to different channels based on their specific requirements. The first channel includes a first valve, the second channel includes a second valve, and the third channel includes a third valve. Each valve provides precise control for its specific ingredient stream, achieving high measurement precision while avoiding unnecessary complexity in channels that don't require it.
3Reliability
If all fluid paths are connected to a common mixing chamber, then the device complexity is reduced, but errors in fluid transfer and path connections increase
Solution Approach 1:
The fluid paths are segmented into separate isolated channels that only converge at the final mixing point (receiving bag). Each channel maintains fluid isolation from others throughout the transfer path, preventing errors in fluid transfer and path connections by ensuring that ingredients remain in their designated streams until intentional mixing occurs at the destination.
4Ease of manufacture
If the manifold requires extensive disassembly for cleaning, then the cleaning thoroughness is improved, but the downtime for cleaning increases
Solution Approach 1:
The manifold channels are designed to be easily accessible and cleanable through the existing valve and port structures. The first, second, and third channels can be flushed and cleaned through their respective intake ports and valves without requiring extensive disassembly of the manifold body, thus maintaining cleaning thoroughness while minimizing cleaning downtime.
Data Source
AI summary
An exemplary compounding system and method can include a transfer set that includes a manifold for assisting in transferring a plurality of ingredients from supply container(s) to a final container. The manifold can include a first channel in fluid communication with at least one primary ingredient, and a second channel in fluid communication with a plurality of secondary ingredients. The first channel and second channel can be in fluid isolation from each other such that the at least one primary ingredient does not mix with the plurality of secondary ingredients within the manifold. The transfer set can include a plurality of inlet lines in fluid communication with the manifold and two outlet lines configured for connection to two separate pumps and eventually being in fluid communication with the final container.