Medication Compounding System with Disposable Transfer Cartridges

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Solution Overview

Problem

Current medication compounding systems face challenges in accurately and efficiently combining medications and diluents while minimizing cross-contamination and requiring human intervention, especially in robotic systems.

Innovation Solution

A medication compounding system comprising a transfer module, medication module, diluent module, and filling module, utilizing transfer cartridges and pumps to accurately transfer and combine medications and diluents, with features like individual transfer cartridges for each medication and replaceable pumps to prevent cross-contamination and facilitate efficient compounding.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If manual compounders are used, then human operation allows flexibility in measuring and transferring medications, but human intervention increases the risk of cross-contamination and reduces efficiency

Engineering Contradiction:
Improvecross-contamination preventionVSAvoidcompounding efficiency
Core Design Contradiction:
ReliabilityVSProductivity

Solution Approach 1:

The system divides the compounding process into separate modules (medication module, diluent module, transfer module, filling module) with dedicated transfer cartridges for each medication. This segmentation prevents cross-contamination by isolating each medication handling path while enabling automated high-speed operation that improves productivity.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The robotic system performs automated medication measurement, transfer, and compounding without human intervention. The system self-manages the entire compounding process including pump control, cartridge replacement, and container filling, eliminating human-induced cross-contamination while maintaining high efficiency.

Inventive Principle:
Principle #25Self-service

2Extent of automation

If robotic compounders are used, then automation reduces human intervention and cross-contamination risk, but complex movements require precise control and increase system complexity

Engineering Contradiction:
Improvehuman intervention reductionVSAvoidsystem complexity
Core Design Contradiction:
Extent of automationVSDevice complexity

Solution Approach 1:

The system employs a universal robotic arm that can perform multiple functions including picking up containers, positioning transfer cartridges, and operating pumps. This multi-functional approach reduces the need for specialized mechanisms for each task, managing system complexity while achieving high automation.

Inventive Principle:
Principle #6Universality (Multi-functionality)

Solution Approach 2:

Transfer cartridges serve as intermediaries between medication containers and the compounding chamber. These standardized cartridges simplify the robotic manipulation process by providing uniform interfaces and containment, reducing the complexity of direct container handling while enabling precise automated control.

Inventive Principle:
Principle #24Intermediary (Mediator)

3Reliability

If individual transfer cartridges are used for each medication, then cross-contamination is minimized, but the number of components increases

Engineering Contradiction:
Improvecross-contamination preventionVSAvoidnumber of components
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The system uses disposable transfer cartridges that are discarded after single use. This approach prevents cross-contamination by ensuring each cartridge is used only once, while the low cost and compact design of individual cartridges make the increased component count manageable. The disposable nature eliminates the need for complex cleaning and sterilization systems.

Inventive Principle:
Principle #27Cheap short-living objects (Disposable)

4Manufacturing precision

If precise measurement and transfer of medications is achieved, then compounding accuracy is improved, but the time required for measurement and transfer increases

Engineering Contradiction:
Improvecompounding accuracyVSAvoidmeasurement and transfer time
Core Design Contradiction:
Manufacturing precisionVSLoss of time

Solution Approach 1:

Medications are pre-filled into transfer cartridges before the compounding process begins. This preliminary action ensures precise dosing is already accomplished during cartridge manufacturing, eliminating the need for time-consuming measurement and transfer operations during actual compounding while maintaining high accuracy through the pre-measured contents.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The system replaces manual measurement and transfer operations with automated pump-based fluid transfer. The pumps provide precise volumetric control through electronic control, achieving accurate medication transfer speeds that are much faster than manual operations while maintaining or improving precision through consistent, repeatable dosing.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Data Source

PatentEP3160419B1System for compounding medication
Publication Date: 2022.10.26 CAREFUSION 303 INC
  • EP3160419B1 patent drawingFigure 1
  • EP3160419B1 patent drawingFigure 2
  • EP3160419B1 patent drawingFigure 3A

AI summary

A compounding system comprising: a transfer module 110 having one or more transfer cartridges 112, each transfer cartridge having an access device coupled to a first pump; a medication module 120 having a medication container, wherein the access device is configured to access the medication container and draws medication from the medication container; a diluent module 140 having one or more diluent containers having a diluent therein, the diluent module comprising a second pump; a filling module 160 that receives medication from the first pump and diluent from the second pump to create a compounded medication comprising at least one medication and diluent, the filling module having a port configured (i) to be coupled to a compounded medication container and (ii) to direct the compounded medication to the compounded medication container through the port.