Pharmaceutical Compounding Verification With Weight-Triggered Imaging

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Solution Overview

Problem

Current systems for preparing pharmaceutical compounds require active user input for image capture during drug preparation, leading to potential errors in verification, and lack integration of image and gravimetric verification methods, which can result in inaccuracies in drug preparation.

Innovation Solution

A system that automatically captures images of drug preparation steps based on weight verification using a scale and image capture device, combining image and gravimetric data for pharmacist review, with a streamlined enclosure to minimize airflow disruption and ensure accurate measurements.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If active user input is required for image capture during drug preparation, then the technician can control when images are taken, but errors may occur that prevent proper verification by the pharmacist

Engineering Contradiction:
Improveverification accuracyVSAvoidoperation complexity
Core Design Contradiction:
ReliabilityVSEase of operation

Solution Approach 1:

The system performs image capture automatically without requiring technician intervention. The processor triggers the image capture device based on detected preparation steps, allowing the system to serve itself rather than requiring active user input for each capture action.

Inventive Principle:
Principle #25Self-service

Solution Approach 2:

The system uses feedback from weight measurements and step detection to automatically trigger image capture. When the processor detects that a preparation step has been completed (through weight change or other indicators), it automatically captures an image, creating a closed-loop verification system.

Inventive Principle:
Principle #23Feedback

2Measurement precision

If only image verification is used for drug preparation verification, then the system is simpler to operate, but it lacks the accuracy of combined image and gravimetric verification

Engineering Contradiction:
Improveverification precisionVSAvoidsystem complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The system merges image verification and gravimetric verification into a unified verification process. Both image data from the image capture device and weight data from the scale are collected and analyzed together by the processor to confirm proper drug preparation, creating a more robust verification system than either method alone.

Inventive Principle:
Principle #5Merging (Combining)

3Productivity

If manual image capture is required at each preparation step, then the technician can ensure proper documentation, but it increases the time required for drug preparation

Engineering Contradiction:
Improvepreparation efficiencyVSAvoiddocumentation completeness
Core Design Contradiction:
ProductivityVSLoss of information

Solution Approach 1:

The system is pre-configured with knowledge of what preparation steps require documentation. The processor automatically triggers image capture at the appropriate moments based on detected preparation events, eliminating the need for technicians to manually decide when images are needed while ensuring complete documentation.

Inventive Principle:
Principle #10Preliminary action

4Measurement precision

If a streamlined enclosure is used for the image capture device, then airflow disruption is minimized and measurement accuracy is improved, but the device complexity increases

Engineering Contradiction:
Improveweight measurement accuracyVSAvoidenclosure complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The enclosure is designed with specific aerodynamic properties only in the regions where airflow affects measurements. The streamlined shape and airflow management features are concentrated around the scale and image capture device areas, while other parts of the preparation station maintain simpler designs.

Inventive Principle:
Principle #3Local quality

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The system ensures accurate and efficient preparation of pharmaceutical compounds by automating image capture and integrating visual and quantitative data, allowing pharmacists to verify preparations quickly and reducing errors, thereby improving the quality and reliability of drug compounding processes.

Implementation Method 1

The scale transmits a signal to the at least one processor to verify a correct amount of at least one component of the pharmaceutical compound based on a weight of the at least one component

Methodology Applied
Scientific EffectGravimetric measurement:

Implementation Method 2

The image capture device captures an image of the object positioned on the scale when the at least one processor verifies the correct amount of the at least one component

Methodology Applied
Scientific EffectImage capture:

Data Source

PatentEP3929543B1System and method for preparing a pharmaceutical compound
Publication Date: 2024.11.06 BECTON DICKINSON & CO
  • EP3929543B1 patent drawingFigure 1
  • EP3929543B1 patent drawingFigure 2
  • EP3929543B1 patent drawingFigure 3

AI summary

A system for preparing a pharmaceutical compound comprises: a computing device comprising a user interface providing an operator with instructions for preparing the pharmaceutical compound and at least one processor operatively connected to the user interface; a scale operatively connected to the at least one processor; and an image capture device operatively connected to the at least one processor and the scale and positioned to capture an image of at least one of a component used in preparing the pharmaceutical compound and the pharmaceutical compound.