Compressed Bone Graft Composition for Faster Implant Integration
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Solution Overview
Problem
Current bone graft materials face challenges such as difficulty in retaining shape, poor blood vessel ingrowth, and undesirable reactions due to the use of bonding substances like glycerol, and require time to heal before tooth implant placement.
Innovation Solution
A bone graft composition is developed using decalcified cortical bone particles that are freeze-dried or hypothermically dehydrated under pressure to form a solid construct without bonding compounds, allowing for rapid bone healing and integration with metallic implants.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If particulate bone allografts are made into paste or past-like material by mixing with bonding substances, then handling characteristics are improved, but the matrices holding the particles become dense and make blood vessel ingrowth difficult to penetrate
Solution Approach 1:
The patent uses a porous collagen sponge matrix instead of dense paste to hold bone particles. The porous structure allows blood vessel ingrowth while maintaining handling characteristics, directly resolving the contradiction between ease of operation and reliability for vascularization.
2Ease of operation
If bonding substances such as glycerol are used to hold bone particles, then handling characteristics are improved, but undesirable reactions are produced
Solution Approach 1:
The patent extracts and eliminates harmful bonding substances like glycerol from the bone graft composition. The collagen sponge matrix provides binding functionality without the harmful chemical reactions, resolving the contradiction between ease of operation and harmful factors.
3Ease of operation
If demineralized bone particles are formed into putties, gels or pastes to improve handling characteristics, then handling is improved, but time must be given to heal before placement of tooth implants
Solution Approach 1:
The patent creates a composite material combining collagen sponge with bone particles (allograft, xenograft, or autograft). This composite provides immediate structural integrity and handling characteristics while supporting rapid bone healing, eliminating the need for extended healing periods before implant placement.
4Reliability
If particulate bone allograft is used, then bone grafting is achieved, but the material is difficult to retain in place
Solution Approach 1:
The patent applies preliminary action by pre-forming the bone particles into a stable collagen sponge matrix structure before implantation. This pre-structuring ensures the material retains its position during and after implantation while maintaining osteoconductive properties for bone grafting.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition provides superior osteoconduction, rapid bone healing, and stable anchorage, eliminating the need for bonding materials and reducing healing time, while promoting new bone growth and integration with dental implants.
Implementation Method 1
dried by freeze-drying or hypothermic dehydration to remove water content and bind the osseous material into a solid structure
Implementation Method 2
dried by freeze-drying or hypothermic dehydration to remove water content and bind the osseous material into a solid structure
Implementation Method 3
packed into a constraining device or placed under pressure between plates of various materials and then dried by freeze-drying or hypothermic dehydration to remove water content and bind the osseous material into a solid structure
Data Source
AI summary
A method of making a bone graft composition is described wherein material including decalcified bone elongated particulate bone is dried in a constraining device or under pressure to produce a solid construct having dimensions corresponding to the constraining device or space to which the material occupied under pressure.