Compressed Decalcified Trabecular Bone Grafts for Socket Repair
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Solution Overview
Problem
Current bone graft treatments for dental applications, such as ridge augmentation and tooth socket obliteration, are slow to heal and prone to infections, requiring time before tooth implantation and lacking in uniformity and mechanical support.
Innovation Solution
A method involving the preparation of compressed and dehydrated decalcified trabecular bone grafts, which are compressed to reduce trabecular spaces, dried to retain the compressed form, and used for rapid healing and osteointegration, potentially impregnated with anti-infection agents, and customized for specific tooth sockets using advanced instrumentation and imaging.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If traditional bone graft materials are used for tooth socket obliteration, then the socket can be filled with graft material, but the healing process is slow and requires extended time before implantation
Solution Approach 1:
The invention changes the physical and chemical parameters of bone graft material by compressing decalcified trabecular bone to increase its density and concentration of growth factors. This parameter change accelerates osteoconduction and osteogenesis, enabling faster healing and allowing implantation to proceed sooner than with traditional graft materials
Solution Approach 2:
The invention creates a composite structure by combining compressed decalcified bone matrix with concentrated growth factors and osteogenic cells. This composite material provides both structural support and biological activity, accelerating the healing process and reducing the waiting period before implantation
2Manufacturing precision
If particulate bone preparations are used, then the graft material can be packed into the socket, but the material lacks uniformity and mechanical support
Solution Approach 1:
The invention applies compression to transform the physical state of decalcified trabecular bone from a loose, non-uniform particulate form to a dense, uniform compact structure. This parameter change simultaneously improves manufacturing precision by creating consistent material properties and enhances strength by providing adequate mechanical support for the socket wall
Solution Approach 2:
The invention creates different local qualities within the graft material by maintaining a compressed outer structure for mechanical support while preserving internal porosity for osteoconduction. This local differentiation provides both uniformity and mechanical strength where needed
3Object-affected harmful factors
If bone graft materials are used in contaminated dental defect fields, then the socket can be treated, but infections are common during healing
Solution Approach 1:
The invention extracts and removes the organic matrix and growth factors from decalcified bone to create a highly concentrated, purified graft material. This extraction process eliminates potential sources of infection while preserving the osteogenic properties, reducing infection risk in contaminated fields
Solution Approach 2:
The invention performs preliminary decalcification and compression of bone material before implantation, creating a sterilizable, concentrated graft product. This preliminary action allows for proper sterilization protocols to be applied, reducing infection risk while maintaining healing efficacy
4Reliability
If decalcified cancellous bone is used, then osteoconduction is improved, but the material lacks structural integrity and compressibility control
Solution Approach 1:
The invention applies controlled compression to decalcified cancellous bone to optimize the balance between porosity and structural integrity. By adjusting compression parameters, the invention maintains sufficient porosity for osteoconduction while providing adequate structural integrity and controlled compressibility for clinical handling
Solution Approach 2:
The invention creates a dynamic structure in the compressed bone graft that can adapt to different loading conditions. The compressed decalcified bone maintains porosity for osteoconduction while developing structural integrity that can withstand physiological loads, providing a dynamic balance between openness and strength
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The compressed decalcified trabecular bone grafts facilitate quicker healing, enhanced osteoconduction, and improved integration by concentrating growth factors, reducing infection risk and providing structural support for immediate tooth implantation.
Implementation Method 1
compressing and drying bone comprising dehydrated decalcified trabecular bone. The bone may be compressed while hydrated from a first form to a second form such that the bone in the second form is compressed relative to the first form
Implementation Method 2
drying may be performed while in the compressed form. When dry, the bone substantially retains the second form and does not revert to the first form when the applied compression is removed
Data Source
AI summary
A method of preparing a bone graft of compressed dehydrated decalcified trabecular bone may include compressing the bone while hydrated from a first form to a second form such that the bone in the second form is compressed relative to the first form. The bone may be dried while compressed. When dry, the bone substantially retains the second form and does not revert to the first form when the compression is removed.