Compression Resistant Implants Using Oxysterol and Ceramic Particles
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Solution Overview
Problem
Current bone graft substitutes face challenges in maintaining compression strength and cohesiveness, especially when incorporating high levels of mineral particles, which can disrupt the matrix and lead to ineffective bone growth due to migration or separation of scaffolding particulates.
Innovation Solution
Development of compression-resistant implants comprising a biodegradable polymer, porous ceramic particles, and an osteogenic agent like Oxy133, which provides a cohesive and adhesive property to bind with other medical implants, ensuring effective bone growth and integration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If substantial levels of mineral particles are incorporated into matrix materials, then bone growth scaffolding is improved, but the matrix mass becomes disrupted and lacks cohesiveness
Solution Approach 1:
A polymer coating is applied to the surface of mineral particles to act as an intermediary layer. This coating prevents direct interaction between mineral particles and the matrix material, eliminating disruption to the matrix mass while maintaining the beneficial scaffolding effect of the mineral particles for bone growth.
Solution Approach 2:
The surface properties of mineral particles are modified through polymer coating, changing parameters such as surface energy, roughness, and chemical composition. These parameter changes enable the particles to integrate into the matrix without disrupting its cohesiveness, while still providing effective bone growth scaffolding.
2Shape
If large mineral particles are used, then scaffolding structure is improved, but particle migration and separation occur
Solution Approach 1:
The polymer coating serves as a mediator that anchors large mineral particles within the matrix material. The coating creates adhesive bonds between the particles and matrix, preventing migration and separation while preserving the large particle scaffolding structure necessary for effective bone growth.
3Quantity of substance
If mineral particles are incorporated to provide scaffolding, then bone growth is promoted, but compressive strength decreases
Solution Approach 1:
The polymer coating on mineral particles acts as a load-transfer intermediary, distributing compressive forces evenly across the particle-matrix interface. This prevents stress concentration and particle dislodgement under compression, maintaining both high mineral content for scaffolding and adequate compressive strength for implant stability.
Solution Approach 2:
The invention creates a composite material system consisting of three components: mineral particles, polymer coating, and matrix material. This composite structure combines the scaffolding benefits of mineral particles with the mechanical strength of the polymer-coated composite, achieving both bone growth promotion and compressive strength requirements.
Data Source
AI summary
Provided is a compression resistant implant configured to fit at or near a bone defect to promote bone growth, the compression resistant implant comprising porous ceramic particles in a biodegradable polymer, and an oxysterol disposed in or on the compression resistant implant. Methods of making and use are further provided.