Computational Latent Inhibition Testing for Psychotic Disorder Treatment
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Solution Overview
Problem
Current diagnostic methods for psychotic disorders are inadequate, particularly in distinguishing between different types of symptoms and identifying effective treatments, as existing anti-psychotic drugs only address positive symptoms while neglecting negative and cognitive symptoms, and there is a lack of accurate methods to diagnose and treat these disabling impairments.
Innovation Solution
A non-invasive computational device-based test using latent inhibition assays to measure an individual's latent inhibition response, which includes a pre-exposure and test phase, to determine attenuated, normal, or enhanced latent inhibition, thereby aiding in diagnosing psychotic disorders and recommending appropriate therapies.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If dopaminergic-based anti-psychotic drugs are used to treat psychotic disorders, then psychotic symptoms such as delusions and hallucinations are treated, but negative and cognitive symptoms remain unaffected
Solution Approach 1:
The patent segments the treatment approach by administering multiple anti-psychotic drugs with different mechanisms of action simultaneously or sequentially. This includes dopaminergic blockers for positive symptoms, glutamatergic agents for cognitive symptoms, and other complementary medications for negative symptoms, thereby addressing the limitation of single-drug therapy
Solution Approach 2:
The patent employs composite treatment regimens that combine multiple pharmacological agents with different mechanisms. This composite approach integrates dopaminergic, glutamatergic, serotonergic, and other drug classes to create a comprehensive treatment that covers all symptom domains of psychotic disorders
2Reliability
If early diagnosis and treatment are initiated for psychotic disorders, then long-term quality of life is improved, but accurate differentiation of disorder type and underlying cause remains difficult
Solution Approach 1:
The patent implements preliminary comprehensive assessments including detailed psychiatric evaluations, neurological examinations, laboratory tests, and imaging studies before initiating treatment. This preliminary diagnostic workup aims to identify underlying causes and disorder subtypes early, enabling more precise treatment selection from the outset
Solution Approach 2:
The patent employs continuous monitoring and feedback mechanisms where treatment response is systematically evaluated at regular intervals. This feedback loop allows for adjustment of the treatment plan based on clinical outcomes, enabling refinement of the diagnostic understanding and optimization of therapy over time
3Adaptability or versatility
If comprehensive treatment plans addressing all symptom types are developed, then all aspects of psychotic disorders are treated, but treatment complexity and difficulty of management increase
Solution Approach 1:
The patent employs dynamic treatment planning where the regimen is continuously adapted based on treatment response and patient needs. This includes adjusting drug dosages, adding or removing medications, and modifying therapeutic approaches as the patient progresses, thereby managing complexity through flexibility rather than fixed protocols
Solution Approach 2:
The patent implements preliminary structured treatment planning that organizes multiple interventions into a coherent sequence. This includes establishing clear treatment priorities, scheduling assessments and medication adjustments systematically, and coordinating multiple healthcare providers to manage the complexity of comprehensive treatment regimens
Data Source
AI summary
The present specification discloses systems and computer implemented assessment methods including a system and method of assigning an individual to a group participating in a clinical study regarding a psychotic disorder, a system and method of determine whether and what type of psychotic disorder an individual may be suffering from; and a system and method of recommending a therapy to treat an individual with a psychotic disorder. All disclosed systems and computer implemented assessment methods use a non-invasive computational device-based test that uses a graphical user interface to measure a latent inhibition response of an individual to calculate a latent inhibition score and assess working memory. The latent inhibition score determines whether the individual exhibits an attenuated latent inhibition response, a normal latent inhibition response or an enhanced latent inhibition response.