Concavo-convex Analysis Plate with Selective Reflection Layer
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Solution Overview
Problem
Existing analysis methods for medical diagnosis are complex, costly, and lack the sensitivity and accuracy required for efficient analyte detection, particularly in methods utilizing antibody-antigen reactions and optical properties.
Innovation Solution
A concavo-convex analysis plate with a selective reflection layer is developed, featuring a substrate with a microscopic structure that changes optical properties upon analyte binding, allowing for high sensitivity and accuracy in analyte detection without the need for sample labeling.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional analysis methods using antibody-antigen reactions are used, then the analysis can be performed, but the sensitivity and quantitative determination accuracy are insufficient
Solution Approach 1:
The patent utilizes a substrate with a concavo-convex structure that exhibits structural color. When an analyte binds to the specific recognition molecule on the substrate surface, the optical properties change, causing a color change that can be visually observed or measured. This eliminates the need for complex labeling operations while providing high sensitivity and accuracy through the structural color effect.
Solution Approach 2:
The patent changes the optical parameters of the substrate by introducing a concavo-convex structure with specific periodicity. This structural modification enables the substrate to exhibit selective light reflection and structural color, which are sensitive to changes in the surface environment caused by analyte binding, thereby improving detection sensitivity without increasing device complexity.
2Measurement precision
If labeling operations are performed to enhance detection sensitivity, then the detection limit improves, but the operation becomes complicated and time-consuming
Solution Approach 1:
The substrate itself provides the detection function through its inherent concavo-convex structure and structural color properties. The substrate automatically responds to analyte binding by changing its optical properties, eliminating the need for external labeling operations. This self-service mechanism simplifies the analysis procedure while maintaining high detection sensitivity.
Solution Approach 2:
The patent employs the color change property of the concavo-convex structure as the detection mechanism. When analyte binds to the specific recognition molecule, the structural color changes, providing a direct visual or measurable signal without requiring any labeling steps, thus simplifying operations while improving detection limit.
3Measurement precision
If complex sensor production methods are used to achieve high sensitivity, then the detection accuracy improves, but the production becomes complicated and expensive
Solution Approach 1:
The patent divides the sensor into two functional components: a substrate with concavo-convex structure providing optical detection capability, and a specific recognition molecule providing analyte binding capability. This segmentation allows each component to be optimized and produced separately using simple methods, then combined to form the complete sensor, simplifying production while maintaining high accuracy.
Solution Approach 2:
The patent creates a composite structure combining the concavo-convex substrate with specific recognition molecules. This composite material approach allows the optical properties of the substrate to be leveraged for high-accuracy detection while the recognition molecules provide specificity, and both components can be produced using relatively simple and cost-effective methods.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The analysis plate enables simple, quick, and cost-effective detection of analytes with enhanced sensitivity and accuracy by utilizing a concavo-convex structure and a selective reflection layer to observe changes in optical properties upon analyte binding.
Implementation Method 1
the substrate has a concavo-convex structure capable of expressing structural color
Implementation Method 2
a band of light reflection caused by the selective reflectivity of the selective reflection layer and a band of light reflection caused by the concavo-convex structure
Data Source
Figure 1~2
Figure 3
Figure 4~5
AI summary
An analysis plate including: a substrate; and a molecule immobilized on a surface of the substrate, the molecule specifically recognizing a measurement target substance, wherein the substrate includes a selective reflection layer in at least part of the layer thereof. Preferably, the surface of the substrate has a concavo-convex structure capable of exhibiting a structural color. Preferably, a band of light reflection caused by a selective reflectivity of the selective reflection layer falls within a band of light reflection caused by the concavo-convex structure. Also provided are an analysis method using the same and a production method thereof.