Concentrated Botulinum Toxin Injection for Longer Wrinkle Control
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Solution Overview
Problem
Current botulinum toxin treatments for facial wrinkles face challenges in achieving a prolonged duration of effect while maintaining safety, leading to frequent injections and potential immunogenic responses.
Innovation Solution
Administering high doses of botulinum toxin using small injection volumes to treat facial wrinkles, specifically in the range of 50 U to 200 U with a total volume of 0.05 ml to 0.35 ml, particularly suitable for small muscles like glabellar frown lines and periorbital lines.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of moving object
If high doses of botulinum toxin are administered using large injection volumes, then the duration of effect is prolonged, but the neurotoxin spreads to nearby muscles causing undesirable paralyzing effects
Solution Approach 1:
The patent applies local quality by using highly concentrated botulinum toxin solutions (high dose per unit volume) that remain localized at the injection site. This concentration approach ensures the toxin acts precisely where injected without diffusing to adjacent muscles, thereby prolonging the duration of effect while preventing spread-related side effects.
Solution Approach 2:
The patent changes the concentration parameter of the botulinum toxin solution, administering high doses (50-200 U) in small volumes (0.05-0.35 ml). This parameter change from low concentration/large volume to high concentration/small volume achieves both prolonged duration and localized action, resolving the contradiction between duration and spread.
2Reliability
If frequent injections are administered to maintain cosmetic effects, then the duration between treatments is reduced, but the risk of neutralizing antibody formation increases
Solution Approach 1:
The patent changes the dosing parameter by administering high doses (50-200 U) that achieve prolonged cosmetic effects. This high-dose approach extends the treatment interval between injections, thereby maintaining reliable cosmetic effects while reducing the frequency of injections and the associated risk of neutralizing antibody formation.
3Object-affected harmful factors
If small injection volumes are used to prevent neurotoxin spread, then the duration of effect is shortened, but the frequency of reinjection increases
Solution Approach 1:
The patent uses highly concentrated solutions where high doses are delivered in small volumes. This creates a localized high-concentration effect that prevents spread while maintaining prolonged duration of action, resolving the contradiction between preventing spread and maintaining duration.
Solution Approach 2:
The patent applies excessive action by using doses (50-200 U) that exceed conventional dosing. This high-dose approach in small volumes ensures sufficient toxin remains at the injection site to maintain effect for extended periods without spreading to adjacent areas, balancing localized action with prolonged duration.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach prolongs the duration of wrinkle amelioration, allowing longer treatment intervals and reducing the frequency of injections, thereby enhancing patient satisfaction and minimizing the risk of neutralizing antibody formation.
Implementation Method 1
Botulinum toxin blocks the release of acetylcholine into the synaptic cleft, thus preventing the cholinergic neuromuscular innervation of striated and smooth muscles required for muscle contraction
Data Source
AI summary
The present invention relates the use of botulinum toxin for the treatment of facial wrinkles, wherein botulinum toxin is administered at high doses (e.g., 50 U to 200 U) using small injection volumes (e.g., 0.05 ml to 0.35 ml). Furthermore, the present invention relates to a method for the treatment of facial wrinkles (e.g., glabellar frown lines) by injecting small volumes of a highly concentrated botulinum toxin solution into a target facial area of a subject.