Conductive Polymer Biosensor for Direct Concentration Detection

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Solution Overview

Problem

Conventional biosensors for measuring the concentration of object materials are complex and costly to manufacture, and often require electrochemical analysis, which can be cumbersome and less accurate.

Innovation Solution

A biosensor comprising a substrate, an electrode layer, a conductive polymer layer, and a bio-recognizing element, where the bio-recognizing element is disposed on the conductive polymer layer, allowing for a chemical reaction that decreases conductivity, enabling measurement of the object material's concentration without the need for electrochemical analysis.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If conventional electrochemical analysis or fluorescence analysis methods are used to measure object material concentration, then measurement capability is achieved, but manufacturing complexity and cost increase

Engineering Contradiction:
Improveobject material concentration measurementVSAvoidmanufacturing method complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The patent extracts the measurement function from complex electrochemical analysis systems and implements it through a simplified conductive polymer-based sensor. By removing unnecessary components and focusing on the essential interaction between bio-recognizing elements and conductive polymer, the device achieves measurement capability with reduced manufacturing complexity

Inventive Principle:
Principle #2Taking out (Extraction)

Solution Approach 2:

The patent replaces complex electrochemical analysis systems with a simpler conductive polymer-based detection system. The measurement function is transferred from elaborate electrochemical instrumentation to a straightforward conductivity change detection in the polymer layer, significantly simplifying the overall device

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

2Measurement precision

If conventional electrochemical analysis or fluorescence analysis methods are used to measure object material concentration, then measurement capability is achieved, but manufacturing cost increases

Engineering Contradiction:
Improveobject material concentration measurementVSAvoidmanufacturing cost
Core Design Contradiction:
Measurement precisionVSEase of manufacture

Solution Approach 1:

The patent employs a disposable sensor design where the conductive polymer layer and bio-recognizing elements are integrated into a single-use device. This eliminates the need for expensive, complex instrumentation and allows for cost-effective mass production of simple sensor units that can be discarded after single use

Inventive Principle:
Principle #27Cheap short-living objects (Disposable)

3Measurement precision

If conventional electrochemical analysis methods are used, then measurement capability is achieved, but the measurement process becomes cumbersome

Engineering Contradiction:
Improveobject material concentration measurementVSAvoidmeasurement process simplicity
Core Design Contradiction:
Measurement precisionVSEase of operation

Solution Approach 1:

The conductive polymer sensor performs self-detection through intrinsic conductivity changes when bio-recognizing elements bind to target molecules. The polymer automatically transduces the binding event into a measurable electrical signal without requiring external electrochemical analysis instrumentation or complex measurement protocols

Inventive Principle:
Principle #25Self-service

4Measurement precision

If conventional electrochemical analysis methods are used, then measurement capability is achieved, but measurement accuracy decreases

Engineering Contradiction:
Improveobject material concentration measurementVSAvoidmeasurement accuracy
Core Design Contradiction:
Measurement precisionVSReliability

Solution Approach 1:

The patent utilizes changes in electrical conductivity parameters of the conductive polymer as bio-recognizing elements bind to target molecules. This direct transduction of molecular binding events into electrical signal changes provides more reliable and accurate measurements compared to conventional electrochemical methods that suffer from interference and complexity

Inventive Principle:
Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The biosensor has a simpler manufacturing method, lower costs, and higher accuracy, allowing for straightforward detection of object material concentrations, such as hydrogen peroxide, without relying on electrochemical analysis.

Implementation Method 1

A chemical reaction takes place between the object and the bio-recognizing element, and the chemical reaction decreases the conductivity of the conductive polymer layer

Methodology Applied
Scientific EffectChemical reaction: Chemical Bonding

Data Source

PatentUS9651515B2Biosensor, manufacturing method of biosensor and method of detecting object
Publication Date: 2017.05.16 NATIONAL TSING HUA UNIVERSITY
  • US9651515B2 patent drawing
  • US9651515B2 patent drawing
  • US9651515B2 patent drawing

AI summary

A biosensor includes a substrate, an electrode layer, a conductive polymer layer and a bio-recognizing element. The electrode layer is disposed on the substrate. The conductive polymer layer is disposed on the electrode layer and partially covers the substrate. The bio-recognizing element is disposed on the conductive polymer layer. A chemical reaction takes place between the object and the bio-recognizing element, and the chemical reaction decreases the conductivity of the conductive polymer layer.