Conical Polymeric Prosthetic Valve for Mitral Replacement

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Solution Overview

Problem

Current prosthetic valves for replacing defective cardiovascular valves face challenges such as adverse inflammatory responses, blood clot formation, and obstruction of the aortic valve outflow tract, leading to complications like heart failure and the need for lifelong anticoagulation with mechanical valves, and immunosuppression with allograft tissue valves, while xenograft valves suffer from calcification and short durability.

Innovation Solution

A method involving a prosthetic 'ribbon structure' valve with a closed distal end, deployed using a catheter assembly and anchor guidewire, which securely attaches to the myocardium without obstructing the aortic valve outflow, utilizing a biocompatible polymer composition that may include pharmacological agents for enhanced attachment and reduced inflammatory response.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If mechanical prosthetic valves are used to replace defective cardiovascular valves, then valve function is restored, but adverse inflammatory responses and blood clot formation occur requiring lifelong anticoagulation

Engineering Contradiction:

Improvevalve functionVSAvoidinflammatory response and blood clot formation

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent applies parameter changes by transitioning from mechanical materials to biocompatible polymer materials with specific physical and chemical properties. The polymer composition parameters (molecular weight, crosslinking density, surface energy) are optimized to reduce thrombogenicity and inflammatory response while maintaining valve functionality.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent employs composite materials by combining biocompatible polymers with pharmacological agents to create a multifunctional prosthetic valve material. This composite structure provides both mechanical valve function and therapeutic effects (anti-thrombotic, anti-inflammatory) simultaneously, eliminating the need for lifelong anticoagulation.

Inventive Principle:

Principle #40Composite materials

2Reliability

If allograft tissue valves are used to replace defective cardiovascular valves, then immune rejection is avoided, but immunosuppression is required

Engineering Contradiction:

Improvevalve functionVSAvoidimmunosuppression requirement

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent applies this principle by using biocompatible polymers that are not subject to immune rejection, eliminating the need for long-term immunosuppression. The material is designed to be biologically inert yet functional, providing a permanent solution without the ongoing medical management required by allografts.

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

3Reliability

If xenograft valves are used to replace defective cardiovascular valves, then immune compatibility is achieved, but calcification and short durability occur

Engineering Contradiction:

Improveimmune compatibilityVSAvoidvalve durability

Core Design Contradiction:

ReliabilityVSDuration of action of stationary object

Solution Approach 1:

The patent applies parameter changes by using synthetic biocompatible polymers with controlled physical properties (elasticity, porosity, surface characteristics) that mimic native valve tissue. These parameter optimizations prevent calcification while ensuring long-term durability, overcoming the limitations of xenograft materials.

Inventive Principle:

Principle #35Parameter changes

4Strength

If prosthetic valves are attached to cardiovascular structures, then secure attachment is achieved, but obstruction of aortic valve outflow tract may occur

Engineering Contradiction:

Improveattachment strengthVSAvoidaortic valve outflow obstruction

Core Design Contradiction:

StrengthVSObject-affected harmful factors

Solution Approach 1:

The patent applies local quality by designing the prosthetic valve with spatially differentiated properties: the attachment region has enhanced anchoring features for secure fixation, while the outflow region maintains open architecture and optimal geometry to prevent obstruction. This localized functional differentiation resolves the contradiction between attachment strength and outflow patency.

Inventive Principle:

Principle #3Local quality

Data Source

PatentUS10945838B2Prosthetic cardiovascular valves and methods for replacing native atrioventricular valves with same

Publication Date: 2021.03.16 CORVIVO CARDIOVASCULAR INC

AI summary

A percutaneous transseptal surgical implantation method for replacing a defective atrioventricular (AV) valve with a conical shaped prosthetic valve formed from a polymeric composition. When the method is employed to replace a native mitral valve, the method positions the prosthetic valve in the mitral valve region, whereby the valve does not obstruct the outflow tract of the aortic valve and prevents the leaflets of the aortic valve from coapting.