Conjugated Linoleic Acid Topical Composition for Extended Bacterial Suppression

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Solution Overview

Problem

Current antimicrobial agents fail to provide long-acting bacterial suppression on skin, which is crucial in preventing infections during prolonged procedures like surgery, as they either have limited application properties or are not easily applied.

Innovation Solution

The use of conjugated fatty acids, such as conjugated linoleic acid, in the form of bacteriostatic materials, esters, or acetates, applied topically in pharmacologically acceptable vehicles, to inhibit bacterial and fungal growth on selected skin areas for extended periods.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Duration of action of moving object

If conventional antimicrobial agents are applied topically, then bacterial suppression is achieved, but the duration of action is limited and requires frequent reapplication

Engineering Contradiction:

Improveduration of bacterial suppressionVSAvoidconsistency of antimicrobial effect

Core Design Contradiction:

Duration of action of moving objectVSReliability

Solution Approach 1:

The patent changes the chemical parameters of the antimicrobial agent by using conjugated fatty acids with specific molecular structures (conjugated double bonds at positions 9,11 or 10,12) and controlled chain lengths. These parameter changes enable the agent to provide prolonged bacterial suppression (up to 24 hours or longer) while maintaining consistent antimicrobial activity, resolving the contradiction between duration and reliability of action

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent employs composite material strategies by formulating conjugated fatty acids in combination with pharmaceutically acceptable carriers, emollients, and other compatible ingredients. This composite approach enhances both the duration and reliability of bacterial suppression while maintaining ease of application and skin compatibility

Inventive Principle:

Principle #40Composite materials

2Reliability

If strong antimicrobial agents are used to ensure effective bacterial suppression, then reliability improves, but ease of operation and skin compatibility deteriorate

Engineering Contradiction:

Improveeffectiveness of bacterial suppressionVSAvoidease of application and skin tolerance

Core Design Contradiction:

ReliabilityVSEase of operation

Solution Approach 1:

The patent utilizes parameter changes by selecting conjugated fatty acids with specific molecular characteristics (conjugated double bond positions, chain lengths of C12-C24) that inherently provide strong antimicrobial activity while maintaining skin compatibility. These parameter optimizations allow the agent to be both highly effective and easy to apply without causing skin irritation, resolving the contradiction between reliability and ease of operation

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent employs conjugated fatty acids that can be applied in simple topical formulations without requiring complex delivery systems or frequent reapplication. The agents provide sustained activity through their inherent chemical stability and mechanism of action, making them practical for routine use while maintaining high effectiveness

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

3Duration of action of moving object

If existing antimicrobial compositions are applied, then some bacterial suppression is achieved, but they fail to provide long-acting suppression required for prolonged procedures

Engineering Contradiction:

Improveduration of bacterial suppressionVSAvoidprotection during prolonged procedures

Core Design Contradiction:

Duration of action of moving objectVSProductivity

Solution Approach 1:

The patent achieves prolonged bacterial suppression (extending to 24 hours or longer) by utilizing conjugated fatty acids with specific molecular parameters including conjugated double bonds at positions 9,11 or 10,12 and chain lengths of C12-C24. These parameter changes enable the agent to maintain protective activity throughout extended surgical procedures and wound care scenarios, directly addressing the productivity requirement for prolonged protection

Inventive Principle:

Principle #35Parameter changes

Data Source

PatentUS9962354B2Method and composition for bacterial or fungal suppression on skin

Publication Date: 2018.05.08 CHANGARIS DAVID G

AI summary

The present disclosure relates to methods and compositions for suppressing the growth of microorganisms on selected areas of the skin for an extended period of time, such as one hour, twenty four hours, seventy two hours, or longer. An area of the skin is selected for the suppression of the growth of microorganisms and a microorganism growth suppressing agent is topically applied to the selected area of the skin. The microorganism growth suppressing agent may be comprised in a pharmacologically acceptable vehicle such as an emulsion or soap. The microorganism growth suppressing agent comprises free conjugated fatty acid such as conjugated linoleic acid.