Contact Area Diffusion Factor for Fat Quantification
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Solution Overview
Problem
Current methods fail to accurately quantify fat content in blood vessels during surgeries like liposuction, leading to high mortality rates due to fat embolism syndrome, and lack effective diagnostic tools for dementia and metabolic diseases like diabetes, which are costly and difficult to manage.
Innovation Solution
A method using the Contact Area Diffusion Factor (CADF) to quantify hydrophobic components in liquids by measuring initial and final contact areas and diameters of a droplet on a solid surface, with equations to calculate fat content, enabling prediction and diagnosis of metabolic diseases and dementia.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional methods are used to monitor fat content during liposuction, then surgical procedures can be performed, but accurate quantification of fat content in blood vessels is not achieved leading to high mortality rates due to fat embolism syndrome
Solution Approach 1:
The patent replaces conventional mechanical/chemical fat analysis methods with an optical measurement system. The CADF method uses contact angle measurement between a test liquid and the sample to detect fat content, substituting complex biochemical assays with a simple optical contact angle measurement that provides real-time quantification of fat emboli in blood vessels
Solution Approach 2:
The patent introduces a test liquid as an intermediary substance to indirectly measure fat content. Instead of directly analyzing blood or fat samples, the method uses a test liquid whose contact angle changes in presence of fat, providing an indirect but accurate measurement mechanism that enables real-time monitoring without complex sample preparation
2Reliability
If expensive dementia treatment is provided, then patient care can be maintained, but it is impossible to completely cure dementia and symptoms can only be temporarily relieved
Solution Approach 1:
The patent enables preliminary diagnosis of dementia and metabolic diseases by measuring fat content in body fluids before symptoms fully develop. The CADF method detects elevated fat levels that precede clinical dementia diagnosis, allowing early intervention and personalized treatment planning before the disease progresses to an irreversible stage
Solution Approach 2:
The patent enables self-diagnosis and monitoring capabilities for dementia risk through simple body fluid sampling. Individuals can collect their own body fluids (urine, sweat, or saliva) and have fat content analyzed using the CADF method, providing accessible diagnostic information without requiring complex medical procedures or expensive equipment
3Productivity
If liposuction is performed frequently, then cosmetic procedures can be provided, but risks such as fat embolism syndrome are not well-known leading to serious deterioration of lung function
Solution Approach 1:
The patent implements real-time feedback monitoring of fat content during liposuction procedures. The CADF method continuously measures fat levels in blood vessels, providing immediate feedback to surgeons about fat emboli presence, enabling them to adjust surgical techniques or terminate procedures when dangerous fat levels are detected, thereby preventing FES despite high procedure volumes
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This method allows for accurate measurement of fat content in body fluids, providing insights into disease development and progression, aiding in early diagnosis and management of conditions like diabetes and dementia, and preventing fat embolism during surgeries.
Implementation Method 1
contacting a droplet of the liquid to a solid surface and measuring an initial contact area (A0) and an initial contact diameter (d0) of a contact surface between the droplet and the solid surface
Implementation Method 2
quantifying the content of hydrophobic components, e.g., fat components contained in a liquid from the CADF value of the liquid droplet
Data Source
AI summary
A method for quantifying a content of hydrophobic components contained in a liquid using a contact area diffusion factor (CADF) of a droplet of the liquid to a solid surface is provided. In addition, the obtained content of the hydrophobic components provides information about prediction for possibility of developing a metabolic disease or dementia, or information about the incidence or progression of a metabolic disease or dementia.