Automated Sample Processing System with Contactless Fluid Handling
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Solution Overview
Problem
Current sample processing systems in research or diagnostic laboratories are limited in throughput, require extensive labor, generate substantial waste, and pose risks to workers due to hazardous materials, with limited versatility in processing different types of samples and extraction methods.
Innovation Solution
A high-throughput sample processing system incorporating contactless fluid dispensing, aspirating, and treatment stations, along with a waste management system, and a control system that dynamically schedules processing based on sample type and status, utilizing reusable pipettes and sterilization to minimize waste and exposure.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If previously known automated processing systems are used to process samples, then processing can be automated, but the sample throughput is limited and processing capacity is low
Solution Approach 1:
The system is divided into multiple independent processing modules including sample dispensing device, treatment stations, aspirators, and waste management system. Each module can process samples independently and simultaneously, enabling parallel processing of multiple sample plates to achieve high throughput while keeping individual module complexity manageable
Solution Approach 2:
The processing system is designed with universal components that can handle multiple sample types and processing protocols. The sample dispensing device and treatment stations are configured to process different sample containers and perform various treatment operations, allowing a single system to serve multiple functions and maintain high productivity across diverse applications
2Loss of substance
If previously known sample processing systems are used, then processing can be performed, but substantial amounts of solid and liquid waste are generated
Solution Approach 1:
The system implements automated waste management with separate collection for liquid and solid waste. Liquid waste is aspirated and collected in a waste container, while solid waste such as used pipette tips is automatically ejected into a designated container. This systematic waste recovery and separation reduces overall waste generation and facilitates efficient disposal
Solution Approach 2:
The waste management system extracts and separates waste materials from the processing workflow. Liquid waste is removed through contactless aspiration, and solid waste is ejected separately, isolating harmful substances from the main processing system to minimize contamination and simplify waste handling
3Object-affected harmful factors
If previously known automated processing systems are used, then automation is provided, but worker exposure to hazardous waste risks increase
Solution Approach 1:
The system introduces contactless treatment stations and automated aspirators as intermediaries between the sample processing area and the operator. These automated components perform fluid handling and waste collection without requiring direct operator contact, creating a protective barrier that reduces exposure to hazardous materials while maintaining high automation
Solution Approach 2:
The waste management system operates autonomously to collect and contain hazardous waste. The automated aspirator collects liquid waste and the solid waste ejection mechanism removes contaminated materials without operator intervention, allowing the system to manage its own waste products safely and reduce worker exposure risks
4Adaptability or versatility
If previously known sample processing systems are used, then processing can be performed, but versatility for extracting different types of target molecules is limited
Solution Approach 1:
The system incorporates dynamically configurable processing parameters and protocols that can be adjusted based on sample type and target molecule. The control system allows modification of dispensing volumes, treatment conditions, and aspiration parameters to optimize extraction for different applications, enabling versatile processing without requiring multiple specialized systems
Solution Approach 2:
The processing system is designed with universal components that can handle multiple sample types including blood, plasma, and other biological fluids. The sample dispensing device and treatment stations are configured to perform various extraction protocols for different target molecules, allowing a single system to provide versatile extraction capabilities across multiple applications
5Loss of substance
If previously known automated processing systems are used, then processing can be automated, but costs increase due to waste disposal requirements
Solution Approach 1:
The system implements automated waste management with separate collection for liquid and solid waste, enabling efficient disposal and recovery processes. By systematically separating and managing waste streams, the system reduces disposal costs associated with mixed hazardous waste while maintaining high automation through integrated waste collection and ejection mechanisms
Data Source
AI summary
Disclosed herein are high-throughput sample processing systems and waste management systems, and methods of using the same.