Continuous Flow Microwave Heating System for Organic Chemistry

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Solution Overview

Problem

Current continuous flow microwave heating systems for organic chemistry and catalysis lack independent control of power and temperature across different channels, leading to limited selectivity and conversion of products, and are constrained by low microwave penetration, which restricts reaction volume and productivity.

Innovation Solution

A continuous flow heating system with multiple modules in series, each equipped with a waveguide, thermal sensors, and an electronic control unit to manage microwave power and temperature independently, ensuring optimal energy transfer and maintaining precise temperature control throughout the reaction process.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Adaptability or versatility

If a single power source is used for microwave heating in continuous flow systems, then the heating source is global over the reaction mixture volume, but the temperature distribution is not uniform and independent control in each path is not achieved

Engineering Contradiction:
Improveindependent power and temperature controlVSAvoidmultiple microwave power sources
Core Design Contradiction:
Adaptability or versatilityVSDevice complexity

Solution Approach 1:

The system divides the continuous flow reactor into multiple independent modules, each with its own microwave power source and temperature control. This segmentation allows independent power and temperature control in each module while maintaining overall system functionality.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

Each module is equipped with localized temperature sensors and control mechanisms that enable independent temperature regulation in specific regions of the flow path, creating local quality control rather than global uniform control.

Inventive Principle:
Principle #3Local quality

2Volume of stationary object

If standard waveguide dimensions are used, then the device structure is simple, but the interaction volume with the reaction medium is limited due to guide sizing constraints and small tube diameter

Engineering Contradiction:
Improveinteraction volumeVSAvoidwaveguide design
Core Design Contradiction:
Volume of stationary objectVSDevice complexity

Solution Approach 1:

The system transitions from traditional waveguide configurations to a modular arrangement where multiple waveguides are stacked or arranged in series, effectively increasing the interaction volume by utilizing additional spatial dimensions while maintaining individual waveguide integrity.

Inventive Principle:
Principle #17Another dimension (Dimensionality change)

3Productivity

If small tube diameter is used in waveguide, then microwave penetration is maintained, but the reaction volume is restricted and productivity is limited

Engineering Contradiction:
Improveflow rateVSAvoidmicrowave penetration
Core Design Contradiction:
ProductivityVSLoss of energy

Solution Approach 1:

The system segments the flow path into multiple smaller channels, each with optimal diameter for microwave penetration, while the collective arrangement of these segments provides sufficient total reaction volume for high productivity.

Inventive Principle:
Principle #1Segmentation

4Manufacturing precision

If waveguide paths are not independent with uniform microwave energy distribution, then the system structure is simple, but the selectivity and conversion of target products are limited

Engineering Contradiction:
Improveselectivity and conversionVSAvoidindependent path control
Core Design Contradiction:
Manufacturing precisionVSDevice complexity

Solution Approach 1:

The system segments the reaction path into independent modules that can be individually optimized for specific reactions, enabling precise control over selectivity and conversion for each transformation step.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The system incorporates dynamic control capabilities where power and temperature parameters can be adjusted in real-time for each module based on reaction requirements, enabling adaptive optimization of selectivity and conversion.

Inventive Principle:
Principle #15Dynamics

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This system allows for selective organic syntheses and catalysis with enhanced productivity by controlling temperature and power distribution, maximizing conversion and selectivity, and enabling higher flow rates than previous systems.

Implementation Method 1

a circulation tube TEi passing through a waveguide Gi configured to heat chemical molecules

Methodology Applied
Scientific EffectMicrowave heating: Microwave Radiation

Implementation Method 2

a waveguide Gi comprising a power source Si emitting an incident power PIGi

Methodology Applied
Scientific EffectDielectric heating: Dielectric Heating

Implementation Method 3

at least one thermal sensor CTi1 for measuring the temperature in the circulation tube TEi

Methodology Applied
Scientific EffectThermal detection: Thermocouple

Implementation Method 4

opening onto an enclosure Ei for maintaining the temperature of the chemical molecules at a defined temperature

Methodology Applied
Scientific EffectThermal insulation: Thermal Insulation

Implementation Method 5

an isolator ISOi protecting the power source Si from a reflected power PRGi

Methodology Applied
Scientific EffectElectromagnetic isolation: Faraday Cage

Implementation Method 6

directional couplers for measuring the incident powers and reflected powers

Methodology Applied
Scientific EffectElectromagnetic wave detection: Waveguide

Implementation Method 7

an impedance matching device

Methodology Applied
Scientific EffectImpedance matching: Electromagnetic Induction

Data Source

PatentEP4311598B1Continuous flow heating system of chemical molecules for organic chemistry reactions and catalysis
Publication Date: 2024.05.29 THALES SA
  • EP4311598B1 patent drawingFigure 1
  • EP4311598B1 patent drawingFigure 2
  • EP4311598B1 patent drawingFigure 3

AI summary

The invention relates to a continuous flow heating system for chemical molecules for organic chemistry and catalysis reactions comprising: - several modules (M1, M2, ...MN), arranged in series, N ≥ 2, a module (Mi) comprising a waveguide (Gi) and a chamber (Ei) for maintaining the temperature of the reactants; and - an electronic control unit (ECU) of the system configured to: - control the incident powers (PIGi) of each waveguide (Gi) emitted by each corresponding source (Si), and the powers delivered (PEi) by each chamber (Ei) for maintaining the temperature, as a function of the temperatures measured by the thermal sensors (CTi1, CTi2, CTi3) and corresponding setpoint temperatures (Tconsi1, Tconsi2, Tconsi3); and - receive measurements of incident power (PIGi) and reflected power (PRGi) intended for the adjustment of impedance matching devices (ADIMPi).