Continuous Glucose Calibration With Threshold-Based Mode Switching
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Solution Overview
Problem
Conventional continuous blood glucose measurement systems face challenges in accurately calibrating blood glucose values when the difference between measured and reference values exceeds a predetermined range, leading to unreliable calibration and potential safety issues.
Innovation Solution
A method for calibrating blood glucose values in continuous systems by selecting a first calibration mode when differences are within a threshold range and a second mode using multiple reference values when differences exceed the threshold, with optional user input and alarms for transmitter attachment and timing.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If a single reference blood glucose value is used for calibration, then the calibration process is simple and quick, but the calibration accuracy is insufficient when the difference between measured and reference values exceeds a predetermined range
Solution Approach 1:
The calibration system dynamically switches between first calibration mode (using single reference value) and second calibration mode (using multiple reference values) based on whether the difference between measured and reference blood glucose values exceeds a predetermined range. This dynamic adaptation resolves the contradiction by adjusting calibration complexity according to the specific calibration situation, ensuring accuracy when needed while maintaining simplicity when conditions permit.
Solution Approach 2:
The system changes the calibration parameter (number of reference values used) based on the calibration situation. When the difference between measured and reference values is within the acceptable range, a single reference value suffices. When the difference exceeds the range, the system transitions to using multiple reference values, thereby adapting the calibration precision to the actual measurement quality.
2Reliability
If multiple reference blood glucose values are used for calibration when differences exceed threshold, then calibration accuracy is improved, but the calibration process becomes more complex and time-consuming
Solution Approach 1:
The system dynamically determines the calibration approach by first checking whether the difference between measured and reference blood glucose values exceeds a predetermined range. Only when this condition is met does the system proceed to use multiple reference values, otherwise it uses a single reference value. This dynamic decision-making process ensures reliability is enhanced only when necessary, minimizing unnecessary calibration time.
Solution Approach 2:
The system uses feedback from the initial comparison between measured and reference values to determine the appropriate calibration mode. The feedback mechanism (checking if the difference exceeds the threshold) guides whether to proceed with simple single-value calibration or more robust multi-value calibration, thereby optimizing the balance between reliability and time consumption.
3Ease of operation
If the system allows free input of reference blood glucose values, then user convenience is improved, but the risk of inputting erroneous values outside the valid range increases
Solution Approach 1:
The system performs preliminary validation by calculating the expected reference blood glucose value range based on the measured blood glucose value and predetermined threshold range before accepting user input. This preliminary action establishes boundaries for valid input, preventing erroneous values from being accepted while still allowing users convenient input within the valid range.
Solution Approach 2:
The system provides feedback to the user when the input reference blood glucose value falls outside the calculated valid range. This feedback mechanism guides users to input correct values while maintaining ease of operation for valid inputs, thereby resolving the contradiction between user convenience and data validity.
Data Source
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AI summary
The present disclosure relates to a method for calibrating a blood glucose value in a continuous blood glucose measurement system. More particularly, blood glucose values can be accurately calibrated according to a calibration mode by differently selecting calibration modes for calibrating blood glucose values on the basis of whether the difference between a blood glucose value measured by a continuous blood glucose measurement system and a reference blood glucose value measured by a separate blood glucose meter is outside a set range. In addition, the blood glucose value of a user can be accurately calibrated by activating, to be scrolled on an input window, only the ranges of the blood glucose value and a reference blood glucose value calculated on the basis of a preset critical range, or by forcibly or automatically calibrating the blood glucose value by a second calibration mode which uses multiple reference blood glucose values, when a reference blood glucose value outside the reference blood glucose value range is input.