Continuous Glucose Monitoring for Adaptive Dialysis Treatment
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Solution Overview
Problem
Dialysis treatments cause unpredictable fluctuations in blood glucose levels, leading to a high risk of asymptomatic hypoglycemia in patients, which can result in cardiovascular events and nerve damage, and existing systems fail to effectively monitor and adapt treatment parameters to mitigate these glycemic episodes.
Innovation Solution
A dialysis system with continuous glucose monitoring (CGM) that uses a sensor to measure blood glucose levels, records their progression, and automatically adjusts treatment parameters or provides user instructions to prevent glycemic episodes by integrating a control unit with the dialysis machine, allowing for personalized therapy planning and intervention.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If continuous glucose monitoring is implemented during dialysis treatment, then the ability to detect glycemic episodes is improved, but the device complexity increases
Solution Approach 1:
The patent combines the glucose sensor, control unit, and dialysis machine into an integrated system. The sensor communicates with the control unit, which is part of the dialysis machine, allowing glucose monitoring and treatment parameter adjustment within a single unified device rather than separate independent systems.
Solution Approach 2:
The dialysis machine's control unit is designed to perform multiple functions: traditional dialysis control and glucose level monitoring. The system can automatically adapt treatment parameters based on glucose data, making the device multi-functional without requiring entirely separate monitoring equipment.
2Reliability
If automatic adaptation of treatment parameters is implemented, then the ability to prevent hypoglycemia is improved, but the control system complexity increases
Solution Approach 1:
The system continuously monitors glucose levels and uses this feedback to automatically adjust dialysis treatment parameters. The control unit receives glucose data from the sensor and modifies treatment parameters in real-time based on the measured glucose progression, creating a closed-loop control system that prevents hypoglycemic episodes.
Solution Approach 2:
The dialysis machine automatically adjusts its own treatment parameters based on glucose monitoring data without requiring external intervention. The control unit autonomously adapts parameters such as dialysis solution glucose concentration and dwell time, enabling the system to self-regulate and prevent glycemic episodes independently.
3Productivity
If glucose diffusion through dialysis membrane is increased, then the dialysis efficiency is improved, but the risk of blood glucose fluctuation increases
Solution Approach 1:
The system dynamically changes the glucose concentration parameter of the dialysis solution based on real-time glucose monitoring data. When hypoglycemia is detected or anticipated, the control unit adjusts the glucose concentration in the dialysis solution to prevent blood glucose levels from dropping too low, while still maintaining effective dialysis function.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system effectively reduces the frequency and intensity of glycemic episodes by continuously monitoring glucose levels and adapting treatment parameters, such as dialysis solution glucose concentration and dwell time, thereby preventing hypoglycemic and hyperglycemic events.
Implementation Method 1
The glucose molecule has a molecular mass of approximately 180 g/mol and does not bind to plasma proteins. It can therefore diffuse through the membrane of a dialysis filter (hemodialysis) or through the peritoneum (peritoneal dialysis) in a simple manner during a dialysis treatment
Implementation Method 2
the control unit is configured to measure the blood glucose level or the interstitial glucose value of a patient using the sensor during a dialysis treatment, to record a time progression of the blood glucose level or of the interstitial glucose values on the basis of the measurement values, and to automatically adapt one or more treatment parameters of the dialysis machine while taking the progression into account
Data Source
AI summary
The invention relates to a system for carrying out dialysis treatment with a dialysis machine, a control unit and a sensor, the sensor being signal-connected to the control unit, and the control unit being designed to measure a patient's blood sugar level or interstitial glucose value during dialysis treatment using the sensor, to record a curve over time of the blood sugar level or interstitial glucose values on the basis of the measured values, and to adapt one or more treatment parameters of the dialysis machine automatically taking the curve into account, or to output an instruction for adaptation of a treatment parameter by a user or for another action by a user.