Contrast Agent Administration Control for Kidney Safety

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Solution Overview

Problem

In minimally invasive medical procedures, there is a challenge in managing the quantity of substances like contrast agents and anesthetics to prevent kidney damage and ensure safe administration, particularly due to the need to minimize iodine use and manage unplanned substance quantities during emergencies.

Innovation Solution

A method that determines a maximum tolerable substance quantity based on patient-specific data and planned procedure information, providing a procedure parameter that compares the required and instantaneous substance quantities to ensure compliance with safe limits, and adapts the administration accordingly.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If iodine-based contrast agents are administered during medical procedures to map vessels under X-ray fluoroscopy, then diagnostic imaging quality is improved, but kidney damage risk increases due to the toxic effects of iodine

Engineering Contradiction:

Improvevessel mapping qualityVSAvoidkidney damage risk

Core Design Contradiction:

Measurement precisionVSObject-affected harmful factors

Solution Approach 1:

The system continuously monitors the cumulative substance quantity administered during the procedure and provides real-time feedback by comparing it against the pre-calculated maximum tolerable value. When the cumulative quantity approaches the limit, the system alerts the operators to reduce further administration, thereby preventing kidney damage while maintaining necessary imaging quality

Inventive Principle:

Principle #23Feedback

Solution Approach 2:

Before the medical procedure begins, the system pre-calculates the maximum tolerable substance quantity based on patient-specific anamnesis data including age, weight, kidney function parameters (eGFR, sCr), and existing illnesses. This preliminary determination establishes a safety threshold that guides contrast agent administration throughout the procedure

Inventive Principle:

Principle #10Preliminary action

2Manufacturing precision

If multiple angiography recordings are performed to detect pre- and intra-procedural states for fusion imaging, then positioning accuracy is improved, but unplanned additional angiographies may exceed the iodine tolerance of the examination object

Engineering Contradiction:

Improvepositioning accuracyVSAvoidtotal iodine quantity

Core Design Contradiction:

Manufacturing precisionVSQuantity of substance

Solution Approach 1:

The system tracks each angiography recording's substance consumption in real-time and provides feedback on the cumulative total. This allows operators to make informed decisions about whether additional unplanned angiographies are safe, preventing excessive iodine accumulation while maintaining necessary positioning accuracy through fusion imaging

Inventive Principle:

Principle #23Feedback

3Reliability

If substances such as anesthetics and anticoagulants are administered during medical procedures to ensure safe operation, then procedural safety is improved, but unplanned substance quantity may exceed tolerable limits and cause harm to the examination object

Engineering Contradiction:

Improveprocedural safetyVSAvoidsubstance toxicity

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The system is designed to monitor multiple types of substances (contrast agents, anesthetics, anticoagulants) simultaneously using a unified approach. It calculates separate maximum tolerable quantities for each substance type based on patient-specific factors and provides comprehensive monitoring, ensuring procedural safety while preventing excessive administration of any substance

Inventive Principle:

Principle #6Universality (Multi-functionality)

Solution Approach 2:

The system continuously monitors cumulative substance quantities for multiple substance types and provides real-time feedback against pre-calculated safety limits. This enables operators to adjust administration rates and prevent exceeding tolerable limits, maintaining procedural safety while avoiding substance toxicity

Inventive Principle:

Principle #23Feedback

Data Source

PatentUS20240021288A1Method and system for providing a procedure parameter

Publication Date: 2024.01.18 SIEMENS HEALTHINEERS AG

AI summary

Contrast agent administration is controlled for medical imaging. Anamnesis data of an examination object is received. A maximum value of a substance quantity is determined based on the anamnesis data. Planning information that has information with regard to a planned sequence of a procedure is received. The procedure includes an administration of substance. An instantaneous value of the substance quantity is acquired. A required value of the substance quantity for the planned procedure is determined based on the instantaneous value and the planning information. A procedure parameter is based on the required value and maximum value of the substance quantity. The procedure parameter has information with regard to a deviation or conformity between the required value and the maximum value of the substance quantity.