Contrast Enhancement for Partial Volume Effect in Medical Imaging

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Solution Overview

Problem

Existing medical image enhancement techniques, both post-processing based and contrast agent based, face limitations such as loss of image information, artifacts, and limited performance in improving image quality by less than 20%. Additionally, these methods struggle to effectively enhance contrast in regions with intrinsic partial volume effects.

Innovation Solution

The proposed method enhances spatial resolution to improve contrast in medical images, particularly for regions with intrinsic partial volume effects. This is achieved by determining a target region, estimating achievable spatial resolution, selecting an increased spatial resolution, and acquiring image data with the increased resolution, thereby enhancing contrast between regions of interest and other tissue regions.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If post-processing methods are used for image enhancement, then image quality is improved by less than 20%, but image information is lost and artifacts are caused

Engineering Contradiction:
Improveimage qualityVSAvoidimage information
Core Design Contradiction:
Measurement precisionVSLoss of information

Solution Approach 1:

The patent applies preliminary action by performing contrast enhancement during the image acquisition phase rather than as a post-processing step. The method adjusts imaging parameters and contrast agent administration before image capture, preserving original image information while achieving enhancement. This resolves the contradiction by preventing information loss that occurs with post-processing methods.

Inventive Principle:
Principle #10Preliminary action

2Measurement precision

If contrast agents are used to increase signal intensity, then contrast between tissues is enhanced, but costs and risks increase

Engineering Contradiction:
Improvetissue contrastVSAvoidcontradiction between contrast enhancement and patient safety
Core Design Contradiction:
Measurement precisionVSObject-affected harmful factors

Solution Approach 1:

The patent applies parameter changes by optimizing imaging parameters (such as pulse sequence parameters, echo time, inversion time) and contrast agent dosage to achieve maximum tissue contrast with minimum contrast agent quantity. This resolves the contradiction by finding the optimal parameter combination that enhances contrast while minimizing risks and costs associated with contrast agent administration.

Inventive Principle:
Principle #35Parameter changes

3Measurement precision

If spatial resolution is increased to improve contrast in regions with intrinsic partial volume effect, then detection sensitivity is improved, but image acquisition complexity increases

Engineering Contradiction:
Improvedetection sensitivityVSAvoidimage acquisition complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The patent applies partial action by selectively applying high spatial resolution imaging only to regions with intrinsic partial volume effects (such as small tumors or fine structures) rather than uniformly across the entire image. This resolves the contradiction by achieving enhanced detection sensitivity where needed while avoiding the complexity of high-resolution acquisition throughout the whole volume.

Inventive Principle:
Principle #16Partial or excessive action

Data Source

PatentUS12217384B2Contrast enhancement method for the objects with intrinsic partial volume effect
Publication Date: 2025.02.04 UNIVERSITY OF CINCINNATI
  • US12217384B2 patent drawing
  • US12217384B2 patent drawing
  • US12217384B2 patent drawing

AI summary

A method for spatial resolution enhanced imaging is provided. The method includes determining a target region of a subject being imaged; estimating an achievable spatial resolution; selecting an increased spatial resolution that is greater than a predetermined spatial resolution and equal to or less than the achievable spatial resolution; and acquiring image data of the target region with the increased spatial resolution. A method for enhancing the contrast between the region of interest and other tissue region in the image data acquired with the increased spatial resolution and other tissue region in image data acquired with the predetermined spatial resolution due to the intrinsic partial volume effect is also provided.