Contrast Injection Control System for Renal Protection
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Solution Overview
Problem
Current medical imaging procedures using contrast media pose a risk of contrast-induced nephropathy, particularly in patients with impaired renal function, due to the burden on the kidneys during clearance of iodinated contrast media, which can lead to kidney damage or failure.
Innovation Solution
A system and method that includes a pressurizing mechanism for delivering a contrast enhancement agent, with a control system that adjusts fluid injection based on renal function measurements, using patient-specific parameters such as age, BMI, and serum creatinine levels to reduce the likelihood of nephropathy, and includes hydration therapy or nephroprotective agents as necessary.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Illumination intensity
If contrast media is injected into the patient's vasculature to enhance imaging procedures, then imaging quality is improved, but renal function deteriorates due to the burden on the kidneys during clearance
Solution Approach 1:
The system dynamically adjusts the injection rate and total volume of contrast media based on real-time or pre-assessed renal function parameters (such as creatinine clearance rate, glomerular filtration rate). By changing these delivery parameters according to the patient's renal capacity, the system optimizes imaging quality while preventing renal overload and contrast-induced nephropathy.
2Device complexity
If a fixed injection protocol is used for contrast media delivery, then device simplicity is maintained, but patient safety deteriorates due to inability to account for individual renal function variations
Solution Approach 1:
The system incorporates feedback mechanisms where renal function parameters (obtained from laboratory tests or point-of-care measurements) are input into the control system. The system then uses this feedback information to automatically adjust injection parameters, ensuring safe and personalized contrast media delivery while maintaining ease of operation through automated decision-making algorithms.
3Measurement precision
If contrast media volume is increased to improve imaging detail, then imaging precision is improved, but nephropathy risk increases due to greater renal burden
Solution Approach 1:
The injection protocol transitions from a static, fixed-volume approach to a dynamic, adaptive approach. The system continuously monitors or considers renal function status and adjusts the contrast media volume and injection rate in real-time or near-real-time, allowing optimization of imaging detail while dynamically managing nephropathy risk based on the patient's actual renal capacity.
Data Source
AI summary
A system which includes a pressurizing mechanism to pressurize a fluid including a contrast enhancement agent for delivery to a patient and a control system in operative connection with the pressurizing mechanism. The control system includes a system to adjust control of fluid injection based upon a measurement of renal function of the patient.