Control Solution Discrimination via Dual-Wavelength Absorbance
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Solution Overview
Problem
Existing methods for discriminating a control solution from whole blood in concentration measuring apparatuses are prone to errors due to variations in solubility and reaction speed of reagents, and are not universally applicable across optical and electrochemical techniques, leading to burdensome user operations and inaccurate measurements.
Innovation Solution
A method that measures luminance at specific wavelength ranges to differentiate between whole blood and a control solution, using a detection wavelength and a reference wavelength to determine the presence of a control solution based on absorbance thresholds, thereby reducing user burden and ensuring accurate discrimination.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If manual mode switching is used for control solution measurement, then the user can operate the apparatus, but the user burden increases and operational errors occur
Solution Approach 1:
The system automatically detects whether a control solution or sample is supplied by the user and switches measurement modes accordingly. The control solution detection unit autonomously identifies the control solution based on its optical properties and triggers automatic mode switching, eliminating the need for manual user operation and reducing operational errors.
2Extent of automation
If reflectance profile discrimination is used, then control solution can be identified, but accuracy decreases due to reagent variations and hematocrit influence
Solution Approach 1:
The system measures absorbance at two different wavelength ranges (first wavelength range with absorption maximum, and second wavelength range without absorption maximum) and uses the ratio or difference of these absorbance values to identify control solutions. This dual-wavelength approach compensates for variations in reagent solubility, reaction speed, and hematocrit values, maintaining high discrimination accuracy under varying conditions.
3Device complexity
If single wavelength measurement is used, then the measurement process is simple, but discrimination accuracy is insufficient due to reagent variations
Solution Approach 1:
Instead of measuring at a single wavelength, the system introduces a second dimension by measuring absorbance at two different wavelength ranges. The first wavelength range corresponds to the absorption maximum of the control solution's IR pigment, while the second wavelength range does not correspond to the absorption maximum. This dual-wavelength measurement provides additional discriminatory information that compensates for reagent variations without significantly increasing device complexity.
4Extent of automation
If electrochemical technique is used for control solution discrimination, then automatic discrimination is achieved, but the method is not applicable to optical measurement systems
Solution Approach 1:
The patent develops an optical-based control solution detection method that can be universally applied to both optical measurement systems and electrochemical measurement systems. By using absorbance measurement at different wavelength ranges, the system achieves automatic control solution discrimination without relying on electrochemical techniques, making it adaptable across different measurement system types.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach allows for reliable automatic discrimination of control solutions from whole blood, reducing the likelihood of erroneous measurements and operational errors, and is applicable to both optical and electrochemical measurement systems, regardless of reagent variations.
Implementation Method 1
measuring luminance of a liquid to be detected at the detection wavelength... measuring the luminance of the liquid to be detected at the reference wavelength
Data Source
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AI summary
The present invention relates to a method for automatically discriminating a control solution from a sample in a measurement system for measuring a target ingredient in the sample by using a measurement wavelength and a reference wavelength, wherein as the control solution, a control solution having a response value lower than a lower limit value (threshold) of a response value, such as absorbance, supposed when luminance of the sample is measured at the reference wavelength and having a response value higher than an upper limit value (threshold) of a response value supposed when luminance of the sample is measured at the detection wavelength for detecting whether the sample is supplied is used.