Controlled Tissue Regeneration Particles via Segmentation

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Solution Overview

Problem

Current tissue regeneration materials face challenges such as variable porosity, structural issues, and limited control over interparticle spacing, which affect their efficacy in supporting tissue formation across large areas.

Innovation Solution

The development of tissue regeneration particles with controlled structures using high-resolution 3-D printing, stereolithography, or injection molding, which incorporate CAD-designed shapes, porosity, and surface features like grooves and pores, enabling consistent and optimized tissue regeneration performance.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Area of moving object

If porous particles are created using conventional void forming techniques, then porosity is introduced to increase surface area for cell attachment, but the porosity exhibits high variability with broad pore size range and poor interconnectivity control

Engineering Contradiction:

Improvesurface area for cell attachmentVSAvoidpore size uniformity and interconnectivity

Core Design Contradiction:

Area of moving objectVSManufacturing precision

Solution Approach 1:

The invention segments the particle into multiple well-defined pore channels with controlled geometry, transitioning from random porous structures to systematically divided pathways that ensure uniform pore sizes and interconnected networks throughout the particle

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The invention changes the manufacturing parameters from conventional spheroidization processes to specialized extrusion or 3D printing processes that enable precise control over pore size, shape, and distribution, transforming the pore structure from variable to highly controlled

Inventive Principle:

Principle #35Parameter changes

2Ease of operation

If tissue regeneration materials are made moldable and injectable by combining particles with carriers, then intraoperative handling and placement are improved, but the particle structure must withstand processing and handling without structural degradation

Engineering Contradiction:

Improveintraoperative handling and placementVSAvoidstructural integrity during handling

Core Design Contradiction:

Ease of operationVSStrength

Solution Approach 1:

The invention performs preliminary structuring of particles with optimized geometry and reinforced walls before implantation, creating particles that are pre-engineered to withstand subsequent handling, mixing, and implantation processes without structural collapse

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The invention uses composite particle structures combining materials with appropriate mechanical properties to maintain structural integrity while allowing moldability and injectability, creating a composite system that balances strength and flexibility

Inventive Principle:

Principle #40Composite materials

3Ease of manufacture

If non-porous materials are used in small particle form, then tissue growth can occur around and between particles, but interparticle spacing control is limited and tissue formation may be slower

Engineering Contradiction:

Improveparticle production simplicityVSAvoidtissue formation rate

Core Design Contradiction:

Ease of manufactureVSSpeed

Solution Approach 1:

The invention intentionally introduces controlled porosity within particles to accelerate tissue formation by providing internal pathways for cell infiltration and nutrient transport, while maintaining ease of manufacture through extrusion or 3D printing processes

Inventive Principle:

Principle #31Porous materials

Data Source

PatentUS20250127965A1Tissue Regeneration Particles with a Controlled Structure

Publication Date: 2025.04.24 BIOGENNIX LLC

AI summary

Disclosed herein are tissue regeneration materials and methods of production and use thereof. Particles with a controlled structure that improves the tissue regeneration process by providing more space for tissue ingrowth are disclosed.