Cannabinoidal Compositions With Controlled-Release Dosing
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Solution Overview
Problem
Existing cannabis-based medicinal products (CBMPs) face challenges in providing a safe and effective dosage form that delivers a broad spectrum of cannabinoids and terpenes with controlled, linear release, as current formulations may not be slow release and can lead to initial high doses followed by rapid diminution, increasing the risk of dependency and addiction.
Innovation Solution
A method of producing a medicinal composition involving mixing cannabis plant extracts with excipients and form-modifying materials to create a controlled release formulation, such as slow-release pellets or granules, ensuring a linear and prolonged therapeutic effect.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of moving object
If current cannabis-based medicinal products are used, then they can provide therapeutic effects, but they may not be slow release and can lead to initial high doses followed by rapid diminution, increasing the risk of dependency and addiction
Solution Approach 1:
The patent changes the release rate parameter of the cannabis extract by incorporating it into a slow-release matrix formulation. This modifies the temporal profile of drug delivery from rapid to sustained release, extending the duration of therapeutic effect and reducing peak plasma concentrations that could lead to dependency.
Solution Approach 2:
The patent creates a composite medicinal composition by combining cannabis plant extract with excipients and form-modifying materials to form a slow-release matrix. This composite structure enables controlled release of the active cannabinoids and terpenes over extended periods, improving safety and reducing addiction risk while maintaining therapeutic efficacy.
2Speed
If cannabis extracts are delivered in conventional formulations, then they can provide rapid therapeutic effect, but they cause initial high doses followed by rapid diminution
Solution Approach 1:
The patent ensures continuous therapeutic action by designing a slow-release formulation that maintains a steady supply of active cannabinoids and terpenes in the bloodstream over 6-7 hours. This eliminates the boom-bust cycle of conventional formulations where high initial doses are followed by rapid decline, providing consistent therapeutic levels throughout the dosing period.
3Reliability
If broad spectrum cannabis extracts are used, then they can activate pharmacological effects via synergistic interactions, but they are difficult to formulate with controlled release properties
Solution Approach 1:
The patent uses excipients and form-modifying materials as intermediary substances that facilitate the incorporation and controlled release of broad-spectrum cannabis extracts. These intermediaries enable the complex mixture of cannabinoids and terpenes to be integrated into a slow-release matrix while maintaining their synergistic pharmacological activities.
Solution Approach 2:
The patent develops a composite formulation system that accommodates the complexity of broad-spectrum extracts by creating a matrix structure capable of holding multiple active compounds. This composite approach allows synergistic interactions to occur while providing controlled release, balancing formulation complexity with manufacturing feasibility.
Data Source
AI summary
Compositions and Methods A method of producing a medicinal composition comprising an extract of cannabis plant material comprises: (i) mixing, for example dissolving, an extract of cannabis plant material in a liquid vehicle to form a liquid mixture: (ii) contacting the liquid mixture with a first excipient: (iii) contacting the combination comprising the liquid mixture and said first excipient with a form modifying material, for example a coating material, to form a precursor composition; and (iv) treating, for example pelletising, the precursor composition to form the medicinal composition.