Convolvulus Extract for Peptic Ulcer and H. pylori Treatment
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Solution Overview
Problem
Current treatments for peptic ulcers and Helicobacter pylori infections often exhibit serious side effects and contribute to antibiotic resistance, necessitating the search for safer, more effective natural therapeutic agents.
Innovation Solution
An ethanolic extract from Convolvulus pilosellifolius, processed into a purified triterpene compound, is administered to inhibit ulcer activity and treat gastrointestinal disorders caused by Helicobacter pylori, using a method involving homogenization, percolation, filtration, and silica gel column chromatography to isolate the active ingredient.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If current treatment regimens (proton pump inhibitors and antibiotics) are used to treat peptic ulcer and H. pylori infection, then ulcer activity is reduced, but serious side effects occur and antibiotic resistance develops
Solution Approach 1:
The invention extracts and isolates the specific active compound (2-propoxyethyl 13-(4-ethoxy-4-oxobutyl)-6b,8a,12b,14a-tetramethyl-5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,14a-tetradecahydropicene-2-carboxylate) from the Convolvulus pilosellifolius plant material through systematic purification processes including percolation, filtration, and silica gel column chromatography. This extraction principle separates the beneficial active ingredient from the plant matrix, providing a purified therapeutic agent that maintains efficacy while reducing unwanted side effects associated with conventional treatments
Solution Approach 2:
The invention changes the chemical parameter by isolating a specific purified compound with defined molecular structure from the crude plant extract. This parameter change from crude extract to purified compound allows for standardized dosing, improved bioavailability, and reduced toxicity while maintaining the anti-ulcerogenic and antibacterial activities against H. pylori
2Reliability
If antibiotics are used to treat H. pylori infection, then bacterial growth is inhibited, but bacterial resistance increases
Solution Approach 1:
The invention employs a natural plant-derived compound as an alternative to conventional antibiotics. This natural compound acts as a single-use therapeutic agent that kills H. pylori bacteria through its inherent antiulcerogenic activity without inducing resistance mechanisms. The compound is administered orally and eliminates the bacterial infection while avoiding the resistance problem that plagues antibiotic therapy
3Object-generated harmful factors
If plant extracts are used to treat peptic ulcer, then side effects are reduced, but treatment efficacy may be insufficient
Solution Approach 1:
The invention applies extraction and purification techniques to isolate the specific active compound from the Convolvulus pilosellifolius plant. This process removes inactive or potentially harmful components while concentrating the therapeutic agent, thereby maintaining the low side effect profile of natural products while enhancing treatment efficacy through standardized purified formulation
Solution Approach 2:
The invention utilizes the natural composite chemistry of the Convolvulus pilosellifolius plant, which contains multiple phytochemicals including alkaloids, flavonoids, and coumarins alongside the active triterpene compound. The synergistic interaction of these natural compounds in the plant extract provides therapeutic benefit with minimal toxicity, and the purified active compound maintains this safety profile while delivering consistent efficacy
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The Convolvulus extract and isolated compound demonstrate potent anti-ulcerogenic activity, reducing peptic ulcers and gastric disorders with minimal side effects, and show significant in vitro antibacterial activity against Helicobacter pylori, with the compound A1 exhibiting the highest efficacy.
Implementation Method 1
The active ingredient in the extract is a compound that was isolated from the extract of C. pilosellifolius as a purified triterpene using silica gel column chromatography
Implementation Method 2
obtaining the extract as a dry powder by drying the solvent under reduced pressure from the filtrate
Data Source
AI summary
The Convolvulus extract for treating peptic ulcer and Helicobacter pylori infection is an ethanolic extract from C. pilosellifolius. The extract is prepared by homogenizing Convolvulus pilosellifolius aerial plant parts to prepare a powder, percolating the powder with an organic solvent to prepare a suspension, filtering the suspension to obtain a filtrate, and obtaining the extract as a dry powder by drying the solvent under reduced pressure from the filtrate. The active ingredient in the extract is a compound that was isolated from the extract of C. pilosellifolius as a purified triterpene using silica gel column chromatography, the compound being named: 2-propoxyethyl 13-(4-ethoxy-4-oxobutyl)-6b,8a12b,14a-tetramethyl-5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,14a-tetradecahydropicene-2-carboxylate. Both the extract and the isolated active ingredient exhibit anti-ulcerogenic activity, and disk diffusion tests show that various strains of H. pylori are susceptible to both the extract and the active ingredient.