Cooling Agent Solubilisation Composition for Ambient Storage
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Solution Overview
Problem
Existing cooling compositions require elevated temperatures for storage and transport, necessitating special heating systems and limiting their production and transport to the same location, leading to increased energy consumption and logistical challenges.
Innovation Solution
A cooling composition comprising 2-hydroxypropyl (2-isopropyl-5-methyl-cyclohexyl) carbonate, (2-isopropyl-5-methyl-cyclohexyl) 2-hydroxypropanoate, and optionally N-ethyl-2-isopropyl-5-methyl-cyclohexanecarboxamide, which dissolves (1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-(1-methylethyl)-cyclohexane-carboxamide, allowing storage and transport at normal temperatures without crystallization.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Stability of the object's composition
If the cooling composition is stored at elevated temperatures to prevent crystallization, then the composition remains stable and usable, but energy consumption increases and special heating systems are required
Solution Approach 1:
The patent changes the chemical parameters of the solvent system by selecting specific solvents with appropriate solubility characteristics that allow the cooling composition to remain stable at lower temperatures (15-30°C) without requiring elevated temperature storage, thus reducing energy consumption while maintaining composition stability
Solution Approach 2:
The patent introduces a co-solvent system where one solvent acts as an intermediary to enhance the solubility of the cooling agent, allowing the composition to remain stable at lower temperatures without crystallization, thereby eliminating the need for continuous heating
2Stability of the object's composition
If the cooling composition is kept warm during transport, then crystallization is prevented, but transport becomes complex and costly requiring special heating systems
Solution Approach 1:
The patent modifies the temperature parameter range for stable storage from elevated temperatures to normal ambient temperatures (15-30°C), and adjusts the solvent composition parameters to achieve adequate solubility at these lower temperatures, thereby eliminating the need for complex heating systems during transport
Solution Approach 2:
The patent extracts the requirement for active heating systems from the transport process by formulating a composition that is inherently stable at ambient temperatures, removing the complexity of temperature control equipment
3Stability of the object's composition
If the cooling composition is produced and used at the same location, then temperature control is simplified, but production flexibility and logistics are limited
Solution Approach 1:
The patent changes the storage temperature parameter from elevated temperatures to normal ambient temperatures (15-30°C), which allows the composition to be produced at one location and transported to another without crystallization, thereby increasing production flexibility and logistical adaptability
Solution Approach 2:
The patent creates a universal cooling composition formulation that can be stored and transported under normal conditions without special temperature control requirements, making it adaptable to various production and distribution scenarios
4Quantity of substance
If more cooling agent is dissolved in the composition, then cooling effect is enhanced, but solubility limitations are reached requiring elevated temperatures
Solution Approach 1:
The patent uses a composite solvent system consisting of multiple solvents with complementary solubility characteristics, where the combination provides enhanced overall solubility for the cooling agent at lower temperatures, allowing higher amounts of cooling agent to be dissolved without requiring elevated storage temperatures
Solution Approach 2:
The patent introduces a co-solvent as an intermediary substance that enhances the solubility capacity of the solvent system, enabling higher concentrations of cooling agent to be maintained in solution at ambient temperatures without crystallization
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition remains stable for days and weeks at temperatures below 25°C, enabling efficient production, storage, and transport without additional heating, and provides enhanced solubility and cooling effects in oral preparations.
Implementation Method 1
2-hydroxypropyl (2-isopropyl-5-methyl-cyclohexyl) carbonate and (2-isopropyl-5-methyl-cyclohexyl) 2-hydroxypropanoate, or a mixture of both compounds, surprisingly, it has been shown that the cooling agent (1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-(1-methylethyl)-cyclohexane-carboxamide can be dissolved in 2-hydroxypropyl (2-isopropyl-5-methyl-cyclohexyl) carbonate, (2-isopropyl-5-methyl-cyclohexyl) 2-hydroxypropanoate
Implementation Method 2
the resulting solution is storage-stable for days and weeks, even at temperatures of 25°C and below. This is particularly surprising because (2-isopropyl-5-methyl-cyclohexyl) 2-hydroxypropanoate is a solid with a melting point of approximately 40°C
Data Source
AI summary
The invention relates to a cooling composition for producing cooling particles, comprising a solvent component and (1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-(1-methylethyl)-cyclohexane-carboxamide dissolved therein. The invention also relates to cooling particles that comprise a cooling composition according to the invention, to oral preparations that comprise cooling particles, to new uses of cooling particles, to a method for producing cooling particles and to the use of a solvent component for dissolving cooling active ingredients.