Solubilized Cooling Compositions for Crystallization-Free Storage
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Solution Overview
Problem
Existing cooling compositions require elevated temperatures for storage and transport, necessitating special equipment and increased energy consumption, and cannot be easily divided into components without crystallization.
Innovation Solution
A cooling composition comprising 2-hydroxypropyl (2-isopropyl-5-methyl-cyclohexyl) carbonate, (2-isopropyl-5-methyl-cyclohexyl) 2-hydroxypropanoate, and N-ethyl-2-isopropyl-5-methyl-cyclohexanecarboxamide, with (1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-(1-methylethyl)-cyclohexane-carboxamide as the cooling agent, which remains stable at room temperature for days to weeks.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Stability of the object's composition
If cooling composition is stored at elevated temperature to prevent crystallization, then storage stability is improved, but energy consumption increases and special equipment is required
Solution Approach 1:
The patent changes the chemical composition parameters of the cooling substance by introducing specific co-solvents (polyols like glycerol, sorbitol, and their esters) that modify the solubility characteristics of the cooling agent. This composition parameter change allows the system to maintain stability at lower temperatures without requiring elevated temperature storage, thereby reducing energy consumption while preserving storage stability.
Solution Approach 2:
The patent introduces co-solvents as intermediary substances that mediate between the cooling agent and the aqueous environment. These co-solvents (such as glycerol monostearate, sorbitan esters) act as surfactants and solubility enhancers, allowing the cooling composition to remain stable at room temperature without requiring special heating equipment, thus resolving the contradiction between stability and energy consumption.
2Stability of the object's composition
If cooling composition is kept warm during transport, then crystallization is prevented, but transport flexibility is reduced and special equipment is needed
Solution Approach 1:
The patent modifies the physical-chemical parameters of the cooling composition by incorporating specific co-solvents that lower the crystallization temperature and broaden the liquid range of the composition. This allows the composition to be transported in standard containers at ambient temperatures without special warming equipment, thereby improving transport flexibility while maintaining crystallization prevention.
Solution Approach 2:
The patent creates a composite cooling composition by combining the cooling agent with multiple co-solvents and surfactants. This composite formulation synergistically prevents crystallization across a wider temperature range, enabling flexible transport conditions without requiring specialized warm-keeping equipment, thus resolving the contradiction between stability and adaptability.
3Adaptability or versatility
If cooling composition is divided into separate components for transport, then transport flexibility is improved, but manufacturing complexity increases
Solution Approach 1:
The patent merges the cooling agent with co-solvents and surfactants into a single homogeneous liquid composition that can be directly transported and applied. This combining approach eliminates the need for complex multi-component assembly processes at the application site, reducing manufacturing complexity while maintaining the flexibility of having the composition ready-to-use upon delivery.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition allows for stable storage and transport at normal temperatures without crystallization, reducing energy costs and enabling flexible production and use scenarios.
Implementation Method 1
A cooling composition for the production of cooling particles, which consists of or comprises a solvent component (A) and dissolved therein a cooling agent (B)
Data Source
AI summary
The present invention relates to a cooling composition for producing cooling particles comprising a solvent component and dissolved therein (1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-(1-methylethyl)-cyclohexane-carboxamide. The present invention further relates to cooling particles comprising a cooling composition according to the invention, oral preparations comprising cooling particles, new uses of cooling particles, a process for the production of cooling particles as well as the use of a solvent component for dissolving cooling agents.