Cooling Body for Capillary Blood Collection Flow Path
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Solution Overview
Problem
Existing blood collection devices using capillary phenomenon for minimally invasive blood collection face issues with blood coagulation, leading to flow path obstruction and inability to collect significant volumes like 1 mL or more, as the devices are not effective in suppressing coagulation during the blood collection process.
Innovation Solution
Incorporating a cooling body within the blood collection device to maintain the flow path at a temperature lower than human body temperature, thereby suppressing blood coagulation and allowing continuous blood flow, which enables the collection of larger volumes by preventing clotting in the flow path.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If a capillary-based blood collection device is used for minimally invasive blood collection, then the invasiveness is reduced, but blood coagulation occurs in the flow path causing flow path obstruction and limiting the collectable volume to only trace amounts
Solution Approach 1:
The patent changes the temperature parameter of the flow path by introducing a cooling mechanism that maintains the flow path at a temperature lower than body temperature. This parameter change suppresses blood coagulation in the capillary flow path, enabling continuous blood flow and allowing collection volumes of 1 mL or more while maintaining the minimally invasive benefit
2Object-affected harmful factors
If a capillary-based blood collection device is used, then minimally invasive collection is achieved, but blood coagulation leads to flow path obstruction
Solution Approach 1:
The patent changes the temperature parameter by cooling the flow path to suppress blood coagulation, thereby maintaining flow path patency and reliability throughout the blood collection process while preserving the minimally invasive characteristic
3Device complexity
If no cooling mechanism is provided, then the device structure remains simple, but blood coagulation occurs limiting collection to trace amounts
Solution Approach 1:
The patent introduces a cooling mechanism that changes the temperature parameter of the flow path. This addition of complexity is justified by the significant improvement in blood collection volume from trace amounts to 1 mL or more, as the cooling suppresses coagulation and enables continuous blood flow through the capillary path
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The cooling mechanism effectively prevents blood coagulation, allowing for the collection of up to 1 mL or more of blood without flow path obstruction, making it suitable for various medical tests and liquid biopsies.
Implementation Method 1
a cooling body for cooling the flow path
Implementation Method 2
a substrate connected to the introduction inlet and including a flow path to flow the blood by capillary action
Data Source
AI summary
A blood collection device including a flow path to flow blood by capillary action capable of collecting a large amount of blood is provided. The blood collection device includes an introduction inlet 23 for introducing the blood of the subject M, a substrate 20 connected to the introduction inlet 23 and including a flow path 25 to flow the blood by capillary action, and a cooling body 30 for cooling the flow path 25.