Topical Cooling Formulation with TRPM8 Modulators and UV Protection

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Solution Overview

Problem

Existing topical formulations that include aloe provide limited cooling and SPF protection, failing to offer a combination of strong cooling sensation and adequate UV protection.

Innovation Solution

A cooling and anesthetic formulation comprising 5-10% menthyl ethylamido oxalyate as an active cooling agent, UV protective agents for at least 30 SPF, and 5-10% cooling oils, along with propellants and anesthetics, to provide superior cooling and sun protection.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Temperature

If aloe based topical formulations are used, then some cooling and SPF protection is provided, but the cooling sensation is weak and SPF protection is insufficient (only about 14 SPF)

Engineering Contradiction:
Improvecooling sensationVSAvoidUV radiation protection
Core Design Contradiction:
TemperatureVSObject-affected harmful factors

Solution Approach 1:

The patent combines multiple cooling agents (menthyl ethylamido oxalyate, cooling oils, menthol, eucalyptol) with UV protective agents in a single topical formulation, achieving both strong cooling sensation and adequate SPF protection (at least 30 SPF) simultaneously

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The formulation uses a composite approach by integrating different functional components: TRPM8 modulators for active cooling, cooling oils for sensory cooling, and UV filters for sun protection, creating a multi-functional product that overcomes the limitations of simple aloe-based formulations

Inventive Principle:
Principle #40Composite materials

2Temperature

If stronger cooling agents are added to enhance cooling sensation, then cooling effect is improved, but formulation complexity increases

Engineering Contradiction:
Improvecooling effectVSAvoidformulation complexity
Core Design Contradiction:
TemperatureVSDevice complexity

Solution Approach 1:

The patent specifies precise concentration ranges for each cooling component (menthyl ethylamido oxalyate at 0.1-10%, cooling oils at 5-10%, menthol at 0.1-5%, eucalyptol at 0.1-5%) to optimize cooling effect while maintaining formulation stability and manufacturability

Inventive Principle:
Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The formulation effectively modulates TRPM8 receptors for active cooling, reduces discomfort, and offers significant UV protection, making it suitable for use in hot environments while preventing skin damage.

Implementation Method 1

an active cooling agent that modulates TRPM8 receptors, wherein the active cooling agent includes 5-10%, by volume, menthyl ethylamido oxalyate

Methodology Applied
Scientific EffectTRPM8 receptor modulation:

Implementation Method 2

UV protective agents that provide an SPF of at least 30

Methodology Applied
Scientific EffectUV radiation absorption: Absorption (EM radiation)

Data Source

PatentUS20240245593A1Cooling formulation for topical application
Publication Date: 2024.07.25 COLD SOLE

AI summary

A cooling formulation having an effective amount of an active cooling agent that modulates TRPM8 receptors, wherein the active cooling agent includes 5-10%, by volume, menthyl ethylamido oxalyate; an effective amount of UV protective agents that provide an SPF of at least 30; and further comprising 5-10% cooling oil.