Cooling Analgesic Patch Adhesive Layer for Sustained Release

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Solution Overview

Problem

Existing patch-type coolants fail to maintain a cool feeling effect and analgesic effect for an extended duration, lacking additional benefits such as anti-inflammatory effects.

Innovation Solution

A patch comprising a nonwoven fabric with an adhesive layer containing a cool feeling agent, local anesthetic, and/or anti-inflammatory analgesic, with a thickness of 0.50 mm or more, and specific component ratios to enhance durability of these effects.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Duration of action of moving object

If the adhesive layer is made thicker to maintain cool feeling and analgesic effects for longer, then the duration of action is improved, but the device complexity and manufacturing difficulty increase

Engineering Contradiction:
Improveduration of cool feeling and analgesic effectVSAvoidadhesive layer structure complexity
Core Design Contradiction:
Duration of action of moving objectVSDevice complexity

Solution Approach 1:

The patent applies parameter changes by optimizing the adhesive layer thickness to a specific range (0.50-1.50 mm) and controlling the gel substrate content (5-50% by weight) to achieve the desired duration of effect without excessive complexity. This quantitative parameter optimization resolves the contradiction between extended duration and structural simplicity.

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent uses composite materials by combining a gel substrate with specific polymers (sodium polyacrylate, polyacrylic acid, or polyvinyl alcohol) to create an adhesive layer that provides both sustained release functionality and appropriate adhesion strength. This composite approach enables long-duration effect while maintaining manufacturability through well-established material combinations.

Inventive Principle:
Principle #40Composite materials

2Duration of action of moving object

If the adhesive layer thickness is increased to enhance sustained release, then the duration of action is improved, but the adhesive force may become excessive or difficult to control

Engineering Contradiction:
Improvesustained release durationVSAvoidadhesive force
Core Design Contradiction:
Duration of action of moving objectVSForce

Solution Approach 1:

The patent resolves this contradiction by precisely controlling multiple parameters: adhesive layer thickness (0.50-1.50 mm), gel substrate content (5-50% by weight), and polymer content (5-50% by weight). This multi-parameter optimization ensures that the adhesive force remains within the desirable range of 10-100 gf/cm² while achieving sustained release over the required duration.

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent applies local quality by creating an infiltration layer where the adhesive layer penetrates into the nonwoven fabric support (0.001-0.500 mm thickness). This localized infiltration provides enhanced anchoring and controlled adhesive force at the interface, while the bulk adhesive layer maintains sustained release properties.

Inventive Principle:
Principle #3Local quality

3Device complexity

If the adhesive layer is made thinner for simpler structure, then the device complexity is reduced, but the duration of cool feeling and analgesic effect decreases

Engineering Contradiction:
Improveadhesive layer structure simplicityVSAvoidduration of cool feeling and analgesic effect
Core Design Contradiction:
Device complexityVSDuration of action of moving object

Solution Approach 1:

The patent demonstrates that by optimizing parameters within specific ranges (adhesive layer thickness 0.50-1.50 mm, gel substrate content 5-50% by weight), it is possible to achieve both structural simplicity and extended duration of effect. The lower bound of 0.50 mm ensures sufficient duration while the upper bound maintains structural simplicity.

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent employs self-service through the infiltration layer that automatically forms as the adhesive layer penetrates into the nonwoven fabric support. This self-infiltration process creates enhanced anchoring and sustained release without requiring additional complex structures or manufacturing steps.

Inventive Principle:
Principle #25Self-service

4Duration of action of moving object

If the adhesive layer thickness is increased to improve sustained release, then the duration of action is improved, but the manufacturing precision requirements increase

Engineering Contradiction:
Improvesustained release durationVSAvoidadhesive layer thickness control
Core Design Contradiction:
Duration of action of moving objectVSManufacturing precision

Solution Approach 1:

The patent establishes a practical thickness range (0.50-1.50 mm) that balances sustained release performance with manufacturing feasibility. This range is sufficiently thick to provide duration but not so thick as to require extreme manufacturing precision, making it suitable for conventional manufacturing processes.

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent reduces overall manufacturing precision requirements by localizing the critical function to the infiltration layer (0.001-0.500 mm), which forms automatically during application. The bulk adhesive layer can be applied with less precision since the infiltration process self-regulates the interface characteristics.

Inventive Principle:
Principle #3Local quality

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The patch maintains a cool feeling and analgesic effect for a longer time, with improved durability and reduced irritation, while preventing uneven component permeation and adhesive shrinkage.

Implementation Method 1

sustained release of the active ingredients

Methodology Applied
Scientific EffectDiffusion: Diffusion

Implementation Method 2

sustained release of the active ingredients

Methodology Applied
Scientific EffectSustained release:

Implementation Method 3

cools the portion where the patch is attached by the heat of vaporization of water

Methodology Applied
Scientific EffectEvaporation: Evaporation

Data Source

PatentUS12629346B2Patch
Publication Date: 2026.05.19 KOBAYASHI PHARMA CO LTD
  • US12629346B2 patent drawing

AI summary

A patch (10) comprising: a nonwoven fabric (1); and an adhesive layer (2) on the nonwoven fabric (1), wherein the adhesive layer (2) comprises a cool feeling agent, a local anesthetic and/or an anti-inflammatory analgesic, and water, and the adhesive layer (2) has a maximum thickness of 0.50 mm or more.