Coordinated Dual-Target Neuromodulation Against Compensation
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Solution Overview
Problem
Modulation of a single arm of the autonomic nervous system often fails to produce sufficient effects for treating medical conditions due to compensation by the other arm, necessitating a more comprehensive neuromodulation approach.
Innovation Solution
Simultaneously modulating two or more neuronal targets, such as sympathetic and parasympathetic nerves, using electrical or non-electrical neuroregulators, with coordinated stimulation or conduction blocks to treat medical conditions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Device complexity
If only one arm of the autonomic nervous system is modulated, then the device complexity is reduced, but the therapeutic efficacy is insufficient due to compensation by the other arm
Solution Approach 1:
The patent segments the neuromodulation system into multiple independent neuroregulators, each targeting a specific neuronal target (sympathetic or parasympathetic nerve). This allows simultaneous modulation of multiple autonomic nervous system arms without requiring a single complex device, thereby reducing overall system complexity while improving therapeutic efficacy through coordinated multi-target intervention.
Solution Approach 2:
The patent combines multiple neuroregulators into a coordinated system that simultaneously modulates both sympathetic and parasympathetic nervous systems. By merging the functions of separate devices into a unified treatment protocol, the system achieves synergistic therapeutic effects that prevent compensatory mechanisms while maintaining manageable device complexity.
2Reliability
If multiple neuronal targets are modulated simultaneously, then the therapeutic efficacy is enhanced, but the device complexity increases
Solution Approach 1:
The system divides the neuromodulation function into separate neuroregulators, each responsible for a specific neuronal target. This segmentation allows for simplified individual device design while achieving complex multi-target modulation through coordinated operation of multiple simpler components.
Solution Approach 2:
The patent employs neuroregulators with universal design principles that can be applied across multiple neuronal targets. Each neuroregulator is designed to work independently but can be integrated into various treatment protocols targeting different nerves, reducing overall system complexity through standardized multi-functional components.
Data Source
AI summary
The present disclosure is directed to the neuromodulation of two or more neuronal targets in treatment of a medical condition. The neuronal targets can be sympathetic nerves, parasympathetic nerves or a combination of sympathetic and parasympathetic nerves. The neuromodulation of the neuronal targets can comprise stimulation of the neuronal target, a conduction block of the neuronal targets or a combination of stimulation and conduction blocks of the neuronal targets. The neuromodulation is performed by one or more neuroregulators which can comprise electrical or non-electrical neuroregulators. The neuromodulation of each of the neuronal targets can include the same or different start/end times, the same or different durations, and/or the same or different neuromodulation patterns. The neuromodulation of the first neuronal target works in cooperation with the neuromodulation of the second neuronal target to treat a medical condition.