Coordination-Ion Polymer Composite for Fast Aqueous Dissolution

Resolve Bottlenecks,
Find Innovative SolutionsGenerate Solutions

Solution Overview

Problem

Medical polymers, particularly injectable thermogels, require prolonged mechanical stirring or heating to dissolve in aqueous solvents, limiting their application in medical and cosmetic fields due to inconvenience and instability during storage and transportation.

Innovation Solution

A polymer composite is developed with a dispersant containing a coordination ion, such as calcium or zinc salts, combined with a water-soluble polymer, which can be quickly dissolved or dispersed in an aqueous solvent by manual shaking, forming a thermally induced gel upon injection.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Stability of the object's composition

If the polymer is preserved in a solid state for stable storage and transportation, then the stability during storage is improved, but the dissolution speed in aqueous solvent deteriorates (requiring more than 12 h of mechanical stirring)

Engineering Contradiction:

Improvestability during storageVSAvoiddissolution speed

Core Design Contradiction:

Stability of the object's compositionVSSpeed

Solution Approach 1:

The patent applies preliminary action by pre-dissolving the polymer in a organic solvent to form a uniform solution before application. This preliminary dissolution step ensures that the polymer is already in a soluble state when applied to the wound, eliminating the need for prolonged mechanical stirring during storage and transportation while maintaining stable solid-state storage properties.

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The patent changes the physical state parameter of the polymer from solid to dissolved state by using an organic solvent system. This parameter change allows the polymer to maintain stable storage properties in solid form while achieving rapid dissolution when applied to the wound, resolving the contradiction between storage stability and dissolution speed.

Inventive Principle:

Principle #35Parameter changes

2Speed

If mechanical stirring is used to accelerate dissolution, then the dissolution speed is improved, but the device complexity and ease of operation deteriorate (requiring special mechanical equipment)

Engineering Contradiction:

Improvedissolution speedVSAvoidease of use in hospital

Core Design Contradiction:

SpeedVSEase of operation

Solution Approach 1:

The patent applies self-service by formulating the polymer in a pre-dissolved state in an organic solvent, allowing the polymer to dissolve automatically upon contact with the wound environment without requiring external mechanical stirring equipment. This eliminates the need for complex mechanical devices while maintaining rapid dissolution, significantly improving ease of operation in hospital settings.

Inventive Principle:

Principle #25Self-service

Solution Approach 2:

The patent replaces the mechanical stirring system with a chemical dissolution approach using an organic solvent formulation. Instead of using mechanical equipment to accelerate dissolution, the polymer is pre-prepared in a soluble state, eliminating the need for mechanical intervention and simplifying the overall system for hospital application.

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

3Ease of operation

If the polymer is dissolved in aqueous solvent directly, then the ease of operation is improved, but the dissolution speed deteriorates (requiring long-time stirring)

Engineering Contradiction:

Improveease of dissolutionVSAvoiddissolution time

Core Design Contradiction:

Ease of operationVSLoss of time

Solution Approach 1:

The patent uses an organic solvent as an intermediary medium to dissolve the polymer before application to the wound. This intermediary approach allows the polymer to be pre-dissolved in a compatible solvent system, achieving rapid dissolution without requiring prolonged stirring time in aqueous environment, thus reducing time loss while maintaining ease of operation.

Inventive Principle:

Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composite can be stored stably and quickly dissolved into an injectable solution, facilitating convenient use in medical applications like drug delivery, tissue adhesion prevention, and cosmetic treatments without the need for mechanical assistance.

Implementation Method 1

the dissolution of polymers is usually a very slow process unless treated by long-time stirring, heating, cooling, etc.

Methodology Applied

Scientific EffectCoordination interaction: Chemical Bonding

Implementation Method 2

they are a kind of special materials usually formed by dissolving amphiphilic block copolymers in water or other aqueous solvents, which are free flowing micellar solutions at low temperature, and can be changed into a physical gel with temperature rise

Methodology Applied

Scientific EffectThermal induced gelation: Gel

Data Source

PatentUS12590187B2Polymer composite capable of being quickly dissolved or dispersed in aqueous solvent and preparation method and application thereof

Publication Date: 2026.03.31 FUDAN UNIVERSITY

AI summary

The present application relates to a polymer composite capable of being quickly dissolved or dispersed in an aqueous solvent, and a preparation method and an application thereof. The polymer composite includes a polymer capable of being thermodynamically dissolved in water or an aqueous solvent and a dispersant containing an ion capable of coordinating with the polymer. The polymer is selected from the group of a water soluble homopolymer and/or copolymer, in particular, thermogelable amphiphilic copolymer.