Copolymer Coating for Flow Passage Anti-Adhesion
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Solution Overview
Problem
Current flow passage devices face issues with biological substance adhesion, leading to clogging and reduced accuracy and sensitivity in analysis, particularly in biotechnology applications, where a simple and effective coating agent to inhibit adhesion on various materials has not been reported.
Innovation Solution
A copolymer with specific anion and cation structures is used to form a coating that can be easily applied to the inner surface of flow passages, inhibiting biological substance adhesion and providing excellent durability and hydrophilicity, especially when combined with hydrophobic groups for enhanced adhesiveness to resins.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a coating agent is applied to inhibit biological substance adhesion, then adhesion resistance is improved, but the complexity of the device increases
Solution Approach 1:
The coating agent is applied in advance to the flow passage inner surface before the device is put into service. This preliminary coating action prevents biological substance adhesion from the start, eliminating the need for complex real-time anti-adhesion mechanisms during operation.
Solution Approach 2:
The patent introduces a coating agent as an intermediary substance between the flow passage surface and biological substances. This coating layer acts as a mediator that prevents direct interaction and adhesion between biological substances and the device surface, simplifying the overall device structure while maintaining anti-adhesion functionality.
2Adaptability or versatility
If various materials are used for flow passage substrate, then adaptability is improved, but finding a universally compatible coating agent becomes more difficult
Solution Approach 1:
The coating agent according to the patent is designed with universal applicability across multiple substrate materials including glass, metal-containing compounds, semimetal-containing compounds, activated charcoal, and resins. This single coating formulation can be used on diverse flow passage materials, eliminating the need to develop separate coating agents for each substrate type.
Solution Approach 2:
The coating agent's composition parameters are optimized to ensure compatibility with various substrate materials. By adjusting the chemical and physical parameters of the coating formulation, the patent achieves broad material compatibility while maintaining effective anti-adhesion performance across different flow passage substrates.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The copolymer coating effectively prevents biological substance adhesion, maintaining sensitivity and accuracy in flow passage devices, and can be applied to various materials like glass, metal compounds, and resins with ease, ensuring a durable and hydrophilic surface.
Implementation Method 1
The copolymer coating effectively prevents biological substance adhesion, maintaining sensitivity and accuracy in flow passage devices, and can be applied to various materials like glass, metal compounds, and resins with ease, ensuring a durable and hydrophilic surface.
Data Source
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AI summary
This is to provide a coating agent for a flow passage which is capable of being coated on the inner surface of the flow passage with an extremely simple and easy operation and having an excellent ability to inhibit adhesion of a biological substance, and a flow passage device having the coating agent for a flow passage on at least part of an inner surface of a flow passage, a platelet-producing flow passage device and a method for manufacturing the same. Provided are a coating agent for a flow passage which comprises a copolymer containing a recurring unit which contains an organic group of the following formula (a) and a recurring unit which contains an organic group of the following formula (b), and a flow passage device having the coating agent for a flow passage on at least part of an inner surface of a flow passage, a platelet-producing flow passage device and a method for manufacturing the same. wherein Ua1, Ua2, Ub1, Ub2, Ub3 and An- are as defined in the present specification and the claims.