Biodegradable Copolymer Nanoparticles for Nodule-Free Tissue Restoration
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Solution Overview
Problem
Conventional injectable tissue restoration materials using hydrophobic biodegradable polymers often cause nodules and side effects due to recombination, particularly when injected into the dermis, and require high operator skill and are prone to microsphere destruction by macrophages.
Innovation Solution
A biodegradable polymeric copolymer composed of hydrophobic and hydrophilic polymers, such as polycaprolactone and polyethyleneglycol, is formed into nanoparticles through self-assembly to prevent nodules and enhance collagen production directly in the dermis.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of stationary object
If hydrophobic biodegradable polymers are used in high weight ratio for tissue restoration, then restoration persistence is improved, but nodule formation occurs due to recombination
Solution Approach 1:
The patent changes the physical-chemical parameters of the polymer system by incorporating hydrophilic biodegradable polymers alongside hydrophobic ones. This parameter modification prevents recombination of hydrophobic polymer chains while maintaining restoration persistence, thereby eliminating nodule formation without sacrificing durability
Solution Approach 2:
The patent creates a composite polymer system combining hydrophobic biodegradable polymers (for persistence) with hydrophilic biodegradable polymers (for solubility and anti-recombination). This composite approach allows the material to maintain structural integrity and persistence while preventing the harmful recombination that leads to nodules
2Reliability
If tissue restoration microparticles are injected into dermal layer to promote collagen production, then tissue restoration effect is improved, but operator skill requirement increases and side effects occur
Solution Approach 1:
The patent changes the particle size parameter from micrometer scale to nanometer scale (10-1000 nm). This size reduction allows the composition to be easily injected into the dermal layer without requiring high operator skill, while the nanoscale particles can still effectively promote collagen production and provide reliable tissue restoration
3Duration of action of stationary object
If micro-sized tissue restoration materials are used to prevent macrophage destruction, then persistence is improved, but hemolysis and mass compression side effects occur
Solution Approach 1:
The patent transitions from micrometer-scale particles to nanometer-scale particles (10-1000 nm), representing a dimensional change in size scale. This nanoscale dimension allows the material to evade macrophage recognition and destruction (improving persistence) while being small enough to avoid hemolysis and mass compression side effects
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The copolymer formulation achieves high collagen production without nodules, demonstrating improved tissue restoration effects and stability in aqueous solutions, reducing side effects and operator skill requirements.
Implementation Method 1
performing self-assembly in an aqueous solution to form nanoparticles
Data Source
AI summary
The present invention provides a composition for restoration of tissue including a biodegradable polymeric copolymer which is obtained by polymerizing a hydrophobic biodegradable polymer and a hydrophilic biodegradable polymer. The composition of the present invention has excellent tissue restoration effects because of high collagen production rate without occurrence of nodules even when injected directly into the dermis, unlike the conventional composition for restoration of tissue.