Copolymer Surface Treating Agent for Blood Treatment Filters
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Solution Overview
Problem
Existing blood treatment filters face issues with surface treating agents that bond weakly with the base material, leading to detachment during sterilization or blood contact, compromising antithrombotic performance and platelet collection rates due to simultaneous adsorption of leukocytes and platelets.
Innovation Solution
A copolymer surface treating agent with a specific molar ratio of monomers, including hydrophilic, basic, and reactive functional groups, is used to effectively coat the base material, forming a chemical bond that prevents detachment and enhances antithrombotic performance, leukocyte removal, and platelet collection.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a surface treating agent is coated on the base material to improve antithrombotic performance, then platelet adhesion is reduced, but the surface treating agent detaches easily during sterilization or washing, compromising long-term performance
Solution Approach 1:
The patent uses a copolymer surface treating agent comprising multiple monomer units with different functional groups (hydrophilic, basic, and reactive groups) that work synergistically. The copolymer structure allows simultaneous achievement of antithrombotic performance through hydrophilic groups and strong bonding through reactive groups that form chemical bonds with the base material.
Solution Approach 2:
The patent specifies precise molar ratios of monomer components (A)/(B)/(C) between 70/15/15 to 98/1/1 to optimize the balance between antithrombotic performance and bonding strength. By controlling the composition parameters of the copolymer, the invention achieves both excellent platelet resistance and stable attachment to the base material.
2Quantity of substance
If a cationic material with quaternary nitrogen is used to improve leukocyte removal rate, then leukocyte adsorption is enhanced, but platelets are simultaneously adsorbed and activated, decreasing platelet collection rate and antithrombotic level
Solution Approach 1:
The patent introduces different functional groups at different locations within the copolymer structure. The basic functional groups (monomer B) provide leukocyte adsorption capability, while the hydrophilic functional groups (monomer A) provide antithrombotic performance. This local differentiation of functions within the copolymer allows selective leukocyte removal without platelet activation.
Solution Approach 2:
The copolymer combines monomer units with basic groups (for leukocyte removal) and hydrophilic groups (for platelet protection) in a specific ratio. This composite structure enables the surface treating agent to perform multiple functions simultaneously: removing leukocytes while maintaining platelet collection and antithrombotic properties.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution maintains excellent antithrombotic performance, improves leukocyte removal, and enhances platelet collection rates by ensuring the surface treating agent remains firmly attached to the base material, even under repeated exposure to blood and sterilization processes.
Implementation Method 1
the surface treating agent is fixed to the base material by a chemical bond between the monomer (C) having a reactive functional group and a reactive functional group of the base material
Implementation Method 2
a monomer (A) having a hydrophilic functional group... inhibit property of adhesion and activation of platelets (antithrombotic performance)
Implementation Method 3
a monomer (B) having a basic functional group... leukocyte removal ability
Data Source
Figure 1
AI summary
A surface treating agent is comprising a copolymer including: a monomer (A) having a hydrophilic functional group of formula (1) or (2) below, a monomer (B) having a basic functional group and a monomer (C) having a reactive functional group as monomer components, wherein the copolymer has a molar ratio of the monomer (A)/(B)/(C) between 70/15/15 to 98/1/1. (wherein (R1)s represent hydrogen or a methyl group, R2 represents an alkyl group having 1 to 4 carbon atoms, n represents an integer of 2 to 4, and R3 and R4 independently represent hydrogen or an alkyl group having 1 to 3 carbon atoms respectively)